DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF70

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_068735.1	Gene:	ZNF70 / 7621	HGNCID:	13140	Length:	446	Species:	Homo sapiens

Alignment Length:	404	Identity:	135/404 - (33%)
Similarity:	201/404 - (49%)	Gaps:	32/404 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 IVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHST 301
            :.|:......:|...::.||.|....||:....||                             :
Human    74 VQHQSIPPGTRPQDDELFGQTFLQKSDLSMCQIIH-----------------------------S 109

  Fly   302 DKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDIC 366
            ::|..|. |.:|.......:...|:.....|:.|:.|.|.|::..|::.|:..||||.|:.|..|
Human   110 EEPSPCD-CAETDRGDSGPNAPHRTPQPAKPYACRECGKAFSQSSHLLRHLVIHTGEKPYECCEC 173

  Fly   367 KKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEH 431
            .|:|::..|.:.|.:.|||:.|::|..|||.:.:...|..|.:.||.:.|:.|..|||.|||...
Human   174 GKAFSQSSHLLRHQIIHTGEKPYECRECGKAFRQSSALTQHQKIHTGKRPYECRECGKDFSRSSS 238

  Fly   432 FTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHT 496
            ...|...||||.|::|..|.|:|.:...|..|.:.||.:.||.|..|.|.|..:.||:.|.|.||
Human   239 LRKHERIHTGERPYQCKECGKSFNQSSGLSQHRKIHTLKKPHECDLCGKAFCHRSHLIRHQRIHT 303

  Fly   497 GETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSY 561
            |:.|:||..|.|||::..:::.|.:.||||.|:||..|.|.|::...|..|.|.|||:.|:.|..
Human   304 GKKPYKCDECGKAFSQSSNLIEHRKTHTGEKPYKCQKCGKAFSQSSSLIEHQRIHTGEKPYECCQ 368

  Fly   562 CKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKE 626
            |.|.|.....|..|.|:|||..|:.|| |.|.|..:..|..|.:.|:.:.|:.||:|.|.|....
Human   369 CGKAFCHSSALIQHQRIHTGKKPYTCE-CGKAFRHRSALIEHYKTHTREKPYVCNLCGKSFRGSS 432

  Fly   627 HLINHMSRCHTGDR 640
            |||.| .:.|:|::
Human   433 HLIRH-QKIHSGEK 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	1/5 (20%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	126/341 (37%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF70	NP_068735.1	C2H2 Zn finger	92..108	CDD:275368	5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..138		4/24 (17%)
		COG5048	138..442	CDD:227381	119/305 (39%)
		C2H2 Zn finger	142..162	CDD:275368	6/19 (32%)
		C2H2 Zn finger	170..190	CDD:275368	6/19 (32%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		C2H2 Zn finger	226..246	CDD:275368	8/19 (42%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..330	CDD:275368	6/19 (32%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..441	CDD:275368	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000