DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and ZNF35

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_003411.3	Gene:	ZNF35 / 7584	HGNCID:	13099	Length:	527	Species:	Homo sapiens

Alignment Length:	556	Identity:	159/556 - (28%)
Similarity:	235/556 - (42%)	Gaps:	117/556 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 PATSGNGGQQVTVTTTSSS-TSSGGSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNV 207
            ||.|..|...:..|...|. ..:.|:....|..|...:||:||
Human    83 PAASTLGSYSLPGTLAKSEILETHGTMNFLGAETKNLQLLVPK---------------------- 125

  Fly   208 ALAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRYH--SERKPFMCQVCGQGFTTSQDLTRHGKI 270
                        |.:|:...|      .||:..|..  ..:.|.:.:.|.:|
Human   126 ------------TEICEEAEK------PLIISERIQKADPQGPELGEACEKG------------- 159

  Fly   271 HIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRC 335
                              |....:.:||...|       .::......||...|:....:   :|
Human   160 ------------------NMLKRQRIKREKKD-------FRQVIVNDCHLPESFKEEENQ---KC 196

  Fly   336 QYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTR 400
            :.....::.....|.:.:...|:.|..|.:|.|.|::..:.|.|...|||:.|.:|..|||.:.:
Human   197 KKSGGKYSLNSGAVKNPKTQLGQKPFTCSVCGKGFSQSANLVVHQRIHTGEKPFECHECGKAFIQ 261

  Fly   401 KEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVR 465
            ..:|..|.|.||.:.|:.|..|||:|::..:.|.|...|:.|...:|:.|.|.|:....|..|.:
Human   262 SANLVVHQRIHTGQKPYVCSKCGKAFTQSSNLTVHQKIHSLEKTFKCNECEKAFSYSSQLARHQK 326

  Fly   466 QHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHK 530
            .|..|..:.|:.|.|||||..:|:.|.|.||||.||.|..|.||||:..:::.|.|.||||.|::
Human   327 VHITEKCYECNECGKTFTRSSNLIVHQRIHTGEKPFACNDCGKAFTQSANLIVHQRSHTGEKPYE 391

  Fly   531 CTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFT 595
            |..|.|.|:...||..|.|.||.:.|:.||.|.|.|::...|..|.|:|:||.
Human   392 CKECGKAFSCFSHLIVHQRIHTAEKPYDCSECGKAFSQLSCLIVHQRIHSGDL------------ 444

  Fly   596 RKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFH 660
                            |:.||.|.|.||...:|:.| .|.|.|::|:||..|||:|..:.:|..|
Human   445 ----------------PYVCNECGKAFTCSSYLLIH-QRIHNGEKPYTCNECGKAFRQRSSLTVH 492

  Fly   661 QRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSH 696
            ||:||.    |:|:.||||...||...||:.|.|:|
Human   493 QRTHTG----EKPYECEKCGAAFISNSHLMRHHRTH 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		C2H2 Zn finger	279..299	CDD:275368	2/19 (11%)
		COG5048	300..723	CDD:227381	134/397 (34%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		C2H2 Zn finger	335..355	CDD:275368	2/19 (11%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	0/19 (0%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	10/19 (53%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF35	NP_003411.3	Globular domain	9..221		32/218 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..38
		COG5048	<214..369	CDD:227381	57/154 (37%)
		C2H2 Zn finger	224..244	CDD:275368	6/19 (32%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		C2H2 Zn finger	336..356	CDD:275368	10/19 (53%)
		C2H2 Zn finger	364..384	CDD:275368	8/19 (42%)
		COG5048	372..>449	CDD:227381	31/104 (30%)
		C2H2 Zn finger	392..412	CDD:275368	8/19 (42%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		C2H2 Zn finger	448..468	CDD:275368	9/20 (45%)
		zf-H2C2_2	460..485	CDD:316026	12/25 (48%)
		zf-C2H2	474..496	CDD:306579	10/21 (48%)
		C2H2 Zn finger	476..496	CDD:275368	9/19 (47%)
		zf-H2C2_2	488..513	CDD:316026	13/28 (46%)
		C2H2 Zn finger	504..524	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810