DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and ZNF33B

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001291962.1	Gene:	ZNF33B / 7582	HGNCID:	13097	Length:	785	Species:	Homo sapiens

Alignment Length:	511	Identity:	210/511 - (41%)
Similarity:	265/511 - (51%)	Gaps:	35/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 DGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPM 276
            ||.|:.  .:.|...|..|:.:..|...::.....|.|.|..||:.|.....||||.::|.|
Human   301 DGVPVK--HYDCGESGNNFRRKLCLSQLQKGDKGEKHFECNECGKAFWEKSHLTRHQRVHTG--- 360

  Fly   277 FTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKT 341
                            |:|         |.|..|.|||..|.:|..|.||||||.||.|..|.|.
Human   361 ----------------EKH---------FQCNQCGKTFWEKSNLTKHQRSHTGEKPFECNECGKA 400

  Fly   342 FTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLAN 406
            |:.|..:..|.|.||||.|::|:.|.|:|.:|.....|...||||.|::|..|||.:....||..
Human   401 FSHKSALTLHQRTHTGEKPYQCNACGKTFYQKSDLTKHQRTHTGQKPYECYECGKSFCMNSHLTV 465

  Fly   407 HMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGES 471
            |.|:||.|.||.|..|||||.:|.|.|.|...|.|:.|:.|:.|.|||..|..|..|...|||..
Human   466 HQRTHTGEKPFECLECGKSFCQKSHLTQHQRTHIGDKPYECNACGKTFYHKSVLTRHQIIHTGLK 530

  Fly   472 PHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTK 536
            |:.|..|.|||..|..|..|.|.||||.||.|..|.|.|:.|..:..|.|.||||.|::|..|.|
Human   531 PYECYECGKTFCLKSDLTIHQRTHTGEKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGK 595

  Fly   537 TFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLN 601
            .|..|.:||.|.|.|||:.|:.|:.|.|||.:|..||.|.|:|.|:.|::|..|.|.|..|..|.
Human   596 IFYNKSYLTKHNRTHTGEKPYECNECGKTFCQKSQLTQHQRIHIGEKPYECNECGKAFCHKSALI 660

  Fly   602 NHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTK 666
            .|.|.|:.:.|:.||.|.|.|..|..||.| .|.|||::|:.|..|||||..|.:|..|.|:||.
Human   661 VHQRTHTQEKPYKCNECGKSFCVKSGLILH-ERKHTGEKPYECNECGKSFSHKSSLTVHHRAHTG 724

  Fly   667 GQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMK 722
                |:...|.:|.|.|..|..|..|.|||:||||:.|..|.|.|.::.||..|.:
Human   725 ----EKSCQCNECGKIFYRKSDLAKHQRSHTGEKPYECNTCRKTFSQKSNLIVHQR 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	2/19 (11%)
		COG5048	300..723	CDD:227381	189/423 (45%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF33B	NP_001291962.1	KRAB	19..78	CDD:214630
		KRAB	19..58	CDD:279668
		C2H2 Zn finger	310..330	CDD:275368	4/19 (21%)
		COG5048	336..681	CDD:227381	158/372 (42%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..374	CDD:290200	13/51 (25%)
		C2H2 Zn finger	366..386	CDD:275368	9/19 (47%)
		zf-H2C2_2	378..403	CDD:290200	14/24 (58%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		zf-H2C2_2	406..429	CDD:290200	10/22 (45%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..457	CDD:290200	10/22 (45%)
		C2H2 Zn finger	450..470	CDD:275368	8/19 (42%)
		zf-H2C2_2	462..485	CDD:290200	13/22 (59%)
		zf-C2H2	476..498	CDD:278523	11/21 (52%)
		C2H2 Zn finger	478..498	CDD:275368	10/19 (53%)
		C2H2 Zn finger	506..526	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..554	CDD:275368	9/19 (47%)
		zf-H2C2_2	546..571	CDD:290200	13/24 (54%)
		C2H2 Zn finger	562..582	CDD:275368	7/19 (37%)
		zf-H2C2_2	575..597	CDD:290200	10/21 (48%)
		C2H2 Zn finger	590..610	CDD:275368	9/19 (47%)
		zf-H2C2_2	602..625	CDD:290200	11/22 (50%)
		C2H2 Zn finger	618..638	CDD:275368	10/19 (53%)
		zf-H2C2_2	631..653	CDD:290200	10/21 (48%)
		C2H2 Zn finger	646..666	CDD:275368	8/19 (42%)
		zf-H2C2_2	658..681	CDD:290200	9/22 (41%)
		COG5048	668..>727	CDD:227381	28/63 (44%)
		C2H2 Zn finger	674..694	CDD:275368	10/20 (50%)
		zf-H2C2_2	690..711	CDD:290200	12/21 (57%)
		C2H2 Zn finger	702..722	CDD:275368	10/19 (53%)
		C2H2 Zn finger	730..750	CDD:275368	8/19 (42%)
		zf-H2C2_2	742..767	CDD:290200	13/24 (54%)
		C2H2 Zn finger	758..778	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.950