DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZSCAN20

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001364305.1	Gene:	ZSCAN20 / 7579	HGNCID:	13093	Length:	1043	Species:	Homo sapiens

Alignment Length:	357	Identity:	133/357 - (37%)
Similarity:	198/357 - (55%)	Gaps:	12/357 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 EHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRS 410
            |.:::|...:..|.|::||.|.|||:|..|::.|...|||:.|::|..|||.::.:.:|..|.|.
Human   695 EKLIDHQGLYLAEKPYKCDTCMKSFSRSSHFIAHQRIHTGEKPYKCLECGKNFSDRSNLNTHQRI 759

  Fly   411 HTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRC 475
            ||.|.|::|..||||||...:...|...||||.|::|..|.|:|.:..:||.|.|.|.|.:|.:|
Human   760 HTGEKPYKCLECGKSFSDHSNLITHQRIHTGEKPYKCGECWKSFNQSSNLLKHQRIHLGGNPDQC 824

  Fly   476 SYCMKTFTRKEHLVNHIRQHTGET-PFKCTYCTKAFTRK-DHMVNHVRQHTGESPHKCTYCTKTF 538
            |.....|.:......|.|..|.|| |.:....:|..... .|..|     :||..::|:.|.::|
Human   825 SEPGGNFAQSPSFSAHWRNSTEETAPEQPQSISKDLNSPGPHSTN-----SGEKLYECSECGRSF 884

  Fly   539 TRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNH 603
            ::...|.:|.|.|||:.|:.|:.|.|:|::...|.||.|.|||:.|:||..|.|.|:.:..|..|
Human   885 SKSSALISHQRIHTGEKPYECAECGKSFSKSSTLANHQRTHTGEKPYKCVDCGKCFSERSKLITH 949

  Fly   604 MRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQ 668
            .|.|:.:.|:.|..|.|.|..:.:||.| .|.|||::|:.|..|||.|....:|:.|||.||.
Human   950 QRVHTGEKPYKCLECGKFFRDRSNLITH-QRIHTGEKPYKCRECGKCFNQSSSLIIHQRIHTG-- 1011

  Fly   669 EMERPFACEKCPKNFICKGHLVSHMRSHSGEK 700
              |:|:.|.:|.|:|....|..:|.|:|:|.|
Human  1012 --EKPYKCTECGKDFNNSSHFSAHRRTHAGGK 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	133/357 (37%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368	2/8 (25%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		C2H2 Zn finger	503..523	CDD:275368	3/20 (15%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368
ZSCAN20	NP_001364305.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
		SCAN	47..132	CDD:396558
		Myb_DNA-bind_4	323..404	CDD:404682
		Myb_DNA-bind_4	483..564	CDD:404682
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	661..692
		COG5048	699..>1029	CDD:227381	126/339 (37%)
		C2H2 Zn finger	712..732	CDD:275368	9/19 (47%)
		C2H2 Zn finger	740..760	CDD:275368	7/19 (37%)
		C2H2 Zn finger	768..788	CDD:275368	8/19 (42%)
		C2H2 Zn finger	796..816	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..873		10/42 (24%)
		C2H2 Zn finger	877..897	CDD:275368	6/19 (32%)
		C2H2 Zn finger	905..925	CDD:275368	8/19 (42%)
		C2H2 Zn finger	933..953	CDD:275368	7/19 (37%)
		C2H2 Zn finger	961..981	CDD:275368	8/20 (40%)
		C2H2 Zn finger	989..1009	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1017..1037	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100