DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF23

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001368913.1	Gene:	ZNF23 / 7571	HGNCID:	13023	Length:	686	Species:	Homo sapiens

Alignment Length:	715	Identity:	229/715 - (32%)
Similarity:	324/715 - (45%)	Gaps:	90/715 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VNIEDISQLFTYHEVFG------KIHGDVV--NHQLAAAHGGQLPPPPPLPPQVTSHAASAAAAA 109
            |..||::..||..|..|      .::.||:  |:...|:.|.     |.|.|.|.|
Human    14 VTFEDVAVYFTQAEWDGLSPAQRTLYRDVMLENYGNVASLGF-----PLLKPAVIS--------- 64

  Fly   110 AAASTNNAAVAAVMASANAAAAAAAAASAGGGLPPATSGNGGQQVTVTTTSSSTS---SGGSTT- 170
                         .....:....::..:||.||      .|.|.|.:.|.:..|.   .|....
Human    65 -------------QLEGGSELGGSSPLAAGTGL------QGLQTVDIQTDNDLTKEMYEGKENVS 110

  Fly   171 -------SGGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAPDGT------PI------ 216
                   |..|..:...||..:.|     |..:||........:    |||      |:
Human   111 FELQRDFSQETDFSEASLLEKQQE-----VHSAGNIKKEKSNTI----DGTVKDETSPVEECFFS 166

  Fly   217 ----------ATGTHV--CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGK 269
                      .||...  |...||...|..:|:.|...:||.:||.|:...:.|.....|.:|.:
Human   167 QSSNSYQCHTITGEQPSGCTGLGKSISFDTKLVKHEIINSEERPFKCEELVEPFRCDSQLIQHQE 231

  Fly   270 IHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFR 334
            .:.....:.|..|...|:.|..|..|.:.||.:|||.|..|.|:|:...|...|...|:||.|::
Human   232 NNTEEKPYQCSECGKAFSINEKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQ 296

  Fly   335 CQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYT 399
            |:.|.|.|:....:..|.|.||||.|::|..|...|:....|:.|...|||:.|::|:.|||.:.
Human   297 CKMCGKAFSVNGSLSRHQRIHTGEKPYQCKECGNGFSCSSAYITHQRVHTGEKPYECNDCGKAFN 361

  Fly   400 RKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHV 464
            ....|..|.|.||.|.|:.|..|||.|........|...||||.|::|..|.|.|.....|:.|.
Human   362 VNAKLIQHQRIHTGEKPYECNECGKGFRCSSQLRQHQSIHTGEKPYQCKECGKGFNNNTKLIQHQ 426

  Fly   465 RQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPH 529
            |.||||.|:.|:.|.|.|:.|..|:.|.|.||||.|::|..|.|||........|:|.||||.|:
Human   427 RIHTGEKPYECTECGKAFSVKGKLIQHQRIHTGEKPYECNECGKAFRCNSQFRQHLRIHTGEKPY 491

  Fly   530 KCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTF 594
            :|..|.|.|:....|..|.|.|||:.|..|:.|.:.||.|.:|.:|.|:|||:.|::|:.|.|.|
Human   492 ECNECGKAFSVNGKLMRHQRIHTGEKPFECNECGRCFTSKRNLLDHHRIHTGEKPYQCKECGKAF 556

  Fly   595 TRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLF 659
            :....|..|.|.|:.:.|..|..|.|.|:...:.|.| .|.|||::||.|:.|||:|.:..:|:.
Human   557 SINAKLTRHQRIHTGEKPFKCMECEKAFSCSSNYIVH-QRIHTGEKPFQCKECGKAFHVNAHLIR 620

  Fly   660 HQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            ||||||.    |:||.|.:|.|.|......:.|...|:.:||:.|::|.|||.....|.:|..::
Human   621 HQRSHTG----EKPFRCVECGKGFSFSSDYIIHQTVHTWKKPYMCSVCGKAFRFSFQLSQHQSVH 681

Fly 725 724
Human 682 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	167/422 (40%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF23	NP_001368913.1	KRAB	14..73	CDD:214630	17/85 (20%)
		C2H2 Zn finger	185..205	CDD:275368	6/19 (32%)
		C2H2 Zn finger	213..233	CDD:275368	4/19 (21%)
		COG5048	229..649	CDD:227381	164/424 (39%)
		C2H2 Zn finger	241..261	CDD:275368	6/19 (32%)
		C2H2 Zn finger	269..289	CDD:275368	6/19 (32%)
		C2H2 Zn finger	297..317	CDD:275368	6/19 (32%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..513	CDD:275368	7/19 (37%)
		C2H2 Zn finger	521..541	CDD:275368	8/19 (42%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
		C2H2 Zn finger	577..597	CDD:275368	7/20 (35%)
		C2H2 Zn finger	605..625	CDD:275368	9/19 (47%)
		C2H2 Zn finger	633..653	CDD:275368	5/19 (26%)
		C2H2 Zn finger	661..681	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11996
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950