DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF182

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001171570.1	Gene:	ZNF182 / 7569	HGNCID:	13001	Length:	639	Species:	Homo sapiens

Alignment Length:	507	Identity:	197/507 - (38%)
Similarity:	279/507 - (55%)	Gaps:	61/507 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 CGKMFQFRYQLIVHRRYHSE-------RKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCF 283
            |.|:|           :|:|       .||:..:.||:|....:.|:.|.:|..|
Human   187 CAKLF-----------FHTEYEKTNPGMKPYGYKECGKGLRRKKGLSLHQRIKNG---------- 230

  Fly   284 NVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHM 348
                              :|||.||.|:|||::|.||..|:|:||||.||.|..|.|.|::|..:
Human   231 ------------------EKPFECTACRKTFSKKSHLIVHWRTHTGEKPFGCTECGKAFSQKSQL 277

  Fly   349 VNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTN 413
            :.|:|.||||.|..|..|.|:|..|...:.||..|||:.|::|:.|||.:|:|.:|..|.::||.
Human   278 IIHLRTHTGERPFECPECGKAFREKSTVIIHYRTHTGEKPYECNECGKAFTQKSNLIVHQKTHTG 342

  Fly   414 ETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYC 478
            |..:.|..||:||.:|.....|...|||:.||.|:.|.|||:.|..|:.|.|.||||.||:|:.|
Human   343 EKTYECTKCGESFIQKLDLIIHHSTHTGKKPHECNECKKTFSDKSTLIIHQRTHTGEKPHKCTEC 407

  Fly   479 MKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEH 543
            .|:|..|..|:.|.|.||||.|::|..|.|.||:|.::..|.|.|:||.|.:|..|.|.|::|.:
Human   408 GKSFNEKSTLIVHQRTHTGEKPYECDVCGKTFTQKSNLGVHQRTHSGEKPFECNECEKAFSQKSY 472

  Fly   544 LTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHS 608
            |..|.|.|||:.|:.|:.|:|.|::|.:|..|.|.||.:.|:||..|.|.|..|..|..|.|.|:
Human   473 LMLHQRGHTGEKPYECNECEKAFSQKSYLIIHQRTHTEEKPYKCNECGKAFREKSKLIIHQRIHT 537

  Fly   609 SDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERP 673
            .:.|:.|.||.|.|::|..||.| .|.|||::|:.|..|||:|..|.....|||:||.    |:|
Human   538 GEKPYECPVCWKAFSQKSQLIIH-QRTHTGEKPYACTECGKAFREKSTFTVHQRTHTG----EKP 597

  Fly   674 FACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNH 725
            :.|.:|.|.|..|.:|:.|.|:|:|:|.|.          ||:.::...|.|
Human   598 YKCTECGKAFTQKSNLIVHQRTHAGKKAHG----------RGHTRKSKFMAH 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	3/16 (19%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	181/422 (43%)
		C2H2 Zn finger	307..327	CDD:275368	11/19 (58%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	2/17 (12%)
ZNF182	NP_001171570.1	KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		COG5048	147..553	CDD:227381	159/404 (39%)
		C2H2 Zn finger	209..228	CDD:275368	5/18 (28%)
		C2H2 Zn finger	236..256	CDD:275368	11/19 (58%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	277..299	CDD:290200	10/21 (48%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	308..329	CDD:290200	10/20 (50%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		zf-H2C2_2	332..357	CDD:290200	10/24 (42%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		zf-C2H2	374..396	CDD:278523	10/21 (48%)
		C2H2 Zn finger	376..396	CDD:275368	9/19 (47%)
		zf-H2C2_2	389..412	CDD:290200	12/22 (55%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		zf-H2C2_2	417..441	CDD:290200	12/23 (52%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		zf-H2C2_2	444..469	CDD:290200	10/24 (42%)
		C2H2 Zn finger	460..480	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..497	CDD:290200	11/24 (46%)
		C2H2 Zn finger	488..508	CDD:275368	8/19 (42%)
		zf-H2C2_2	500..523	CDD:290200	10/22 (45%)
		C2H2 Zn finger	516..536	CDD:275368	8/19 (42%)
		zf-H2C2_2	529..553	CDD:290200	10/23 (43%)
		C2H2 Zn finger	544..564	CDD:275368	10/20 (50%)
		zf-H2C2_2	557..579	CDD:290200	12/22 (55%)
		C2H2 Zn finger	572..592	CDD:275368	9/19 (47%)
		zf-H2C2_2	587..609	CDD:290200	11/25 (44%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..639		7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950