DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF16

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001025147.2	Gene:	ZNF16 / 7564	HGNCID:	12947	Length:	682	Species:	Homo sapiens

Alignment Length:	525	Identity:	198/525 - (37%)
Similarity:	277/525 - (52%)	Gaps:	10/525 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 NGGGQNVALAPD-----GTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTT 260
            ||.....:|:|:     ..|.....|..|:.|:.||....|..|....:...|.:|..||:.|..
Human   156 NGFDSRFSLSPNLMACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLICNECGKTFQG 220

  Fly   261 SQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFR 325
            :.||.:...:|.|...|.|..|...|:.|:.|:...:.|.::|.:.|:.|.|.|........|..
Human   221 NPDLIQRQIVHTGEASFMCDDCGKTFSQNSVLKNRHRSHMSEKAYQCSECGKAFRGHSDFSRHQS 285

  Fly   326 SHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQ 390
            .|:.|.|:.|..|.|.|::...:..|.:.|..|.|:.|:.|.|:|.|..:.:.|...|:|:.|:.
Human   286 HHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKPYV 350

  Fly   391 CDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFT 455
            |..|||.:.|..:|..|.|:||.|.||.|..|||:||:..|...|...||||.|:.|:.|.|.|:
Human   351 CSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYECNDCGKPFS 415

  Fly   456 RKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHV 520
            |..:|:.|.|.||||.|::||.|.|.|::...|:.|.|.||||.|..|..|.|||:....:..|.
Human   416 RVSNLIKHHRVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRKHQ 480

  Fly   521 RQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPH 585
            ..||||.|::|:.|.|.|:....|..|...||||.|:.|..|.|||.|..:|..|.|:|||:.|:
Human   481 IIHTGEKPYRCSVCGKAFSHSSALIQHQGVHTGDKPYACHECGKTFGRSSNLILHQRVHTGEKPY 545

  Fly   586 KCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKS 650
            :|..|.|||::...|..|.|.|:...||.||.|.|.|.|..:||:| .:.|||::|:||..|||.
Human   546 ECTECGKTFSQSSTLIQHQRIHNGLKPHECNQCGKAFNRSSNLIHH-QKVHTGEKPYTCVECGKG 609

  Fly   651 FPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERG 715
            |....:|:.||..||.    |||:.|.:|.|.|..:..|:.|.|.|:|.||:.|..|.|||.:|.
Human   610 FSQSSHLIQHQIIHTG----ERPYKCSECGKAFSQRSVLIQHQRIHTGVKPYDCAACGKAFSQRS 670

  Fly   716 NLKRH 720
            .|.:|
Human   671 KLIKH 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	170/421 (40%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF16	NP_001025147.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Necessary for transcription activation	62..210		13/53 (25%)
		COG5048	<160..369	CDD:227381	59/208 (28%)
		C2H2 Zn finger	187..203	CDD:275368	5/15 (33%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..259	CDD:275368	5/19 (26%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		Required for nuclear localization	268..393		44/124 (35%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		COG5048	303..675	CDD:227381	156/376 (41%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		Required for nuclear localization	341..373		12/31 (39%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	407..427	CDD:275368	8/19 (42%)
		C2H2 Zn finger	435..455	CDD:275368	8/19 (42%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		Required for nuclear localization	473..503		10/29 (34%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	519..539	CDD:275368	9/19 (47%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		C2H2 Zn finger	575..595	CDD:275368	9/20 (45%)
		C2H2 Zn finger	603..623	CDD:275368	8/19 (42%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		C2H2 Zn finger	659..679	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860