DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF14

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_066358.2	Gene:	ZNF14 / 7561	HGNCID:	12924	Length:	642	Species:	Homo sapiens

Alignment Length:	485	Identity:	181/485 - (37%)
Similarity:	247/485 - (50%)	Gaps:	9/485 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 TGT--HVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCI 280
            ||.  :.|..|||.|.:......|.|.|:.:||:.|:.||:.|...|...:|.  |.|...:.|.
Human   164 TGVKPYECKQCGKAFIYYQPFQRHERTHAGQKPYECKQCGKTFIYYQSFQKHA--HTGKKPYECK 226

  Fly   281 VCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRK 345
            .|...|....|.:||.:.|:.:||:.|..|.|.|:...:...|.|:||||.|::|:.|.|.|:..
Human   227 QCGKAFICYQSFQRHKRTHTGEKPYECKQCGKAFSCPTYFRTHERTHTGEKPYKCKECGKAFSFL 291

  Fly   346 EHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRS 410
            .....|.|.|:||.|:.|..|.|:|.....:..|.:.|||..|::|..|||.:........|.|:
Human   292 SSFRRHKRTHSGEKPYECKECGKAFFYSASFRAHVIIHTGARPYKCKECGKAFNSSNSCRVHERT 356

  Fly   411 HTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRC 475
            |..|.|:.|:.||||||.......|...||||.|:.|..|.|||:....|..|...||||.|:.|
Human   357 HIGEKPYECKRCGKSFSWSISLRLHERTHTGEKPYECKQCHKTFSFSSSLREHETTHTGEKPYEC 421

  Fly   476 SYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTR 540
            ..|.|||:....|..|.|.|..|.|::|..|.|||....:...|.|.||||.|::|..|.|.|.|
Human   422 KQCGKTFSFSSSLQRHERTHNAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYECKQCGKVFIR 486

  Fly   541 KEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMR 605
            ......|.|.|||:.|:.|..|.|||:....|..|.::|||:.|.:|:.|.|.|.|...:..|.|
Human   487 SSSFRLHERTHTGEKPYECKLCGKTFSFSSSLREHEKIHTGNKPFECKQCGKAFLRSSQIRLHER 551

  Fly   606 QHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEM 670
            .|:.:.|:.|..|.|.|........| .|.|||::|:.|:.|||:|....::..|:||||.
Human   552 THTGEKPYQCKQCGKAFISSSKFRMH-ERTHTGEKPYRCKQCGKAFRFSSSVRIHERSHTG---- 611

  Fly   671 ERPFACEKCPKNFICKGHLVSHMRSHSGEK 700
            |:|:.|::|.|.||...|...|.|:|.|||
Human   612 EKPYECKQCGKAFISSSHFRLHERTHMGEK 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	154/401 (38%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF14	NP_066358.2	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	80..97	CDD:275368
		C2H2 Zn finger	105..125	CDD:275368
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	171..191	CDD:275368	7/19 (37%)
		C2H2 Zn finger	199..217	CDD:275368	6/19 (32%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		zf-H2C2_2	237..262	CDD:290200	10/24 (42%)
		COG5048	249..633	CDD:227381	148/388 (38%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	265..289	CDD:290200	10/23 (43%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	293..316	CDD:290200	9/22 (41%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		C2H2 Zn finger	365..385	CDD:275368	8/19 (42%)
		zf-H2C2_2	377..401	CDD:290200	10/23 (43%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		zf-H2C2_2	405..429	CDD:290200	11/23 (48%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		C2H2 Zn finger	449..469	CDD:275368	7/19 (37%)
		zf-H2C2_2	461..486	CDD:290200	11/24 (46%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		zf-H2C2_2	517..542	CDD:290200	10/24 (42%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		C2H2 Zn finger	561..581	CDD:275368	6/20 (30%)
		zf-H2C2_2	574..596	CDD:290200	10/22 (45%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		zf-H2C2_2	601..626	CDD:290200	11/28 (39%)
		C2H2 Zn finger	617..637	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860