DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF12

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_057349.2	Gene:	ZNF12 / 7559	HGNCID:	12902	Length:	697	Species:	Homo sapiens

Alignment Length:	576	Identity:	198/576 - (34%)
Similarity:	284/576 - (49%)	Gaps:	57/576 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 GNGGGQNVALAPDGTP---IATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQG---- 257
            ||..|:...:..:..|   ||....:||.|.|......:.|.....::..|...|..||:.
Human   114 GNVPGKTFDVETNPVPSRKIAYKNSLCDSCEKCLTSVSEYISSDGSYARMKADECSGCGKSLLHI 178

  Fly   258 --------------------FTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKR---- 298
                                :|.::: :.:.||.|....|..|.|...|..:|....||:.
Human   179 KLEKTHPGDQAYEFNQNGEPYTLNEE-SLYQKIRILEKPFEYIECQKAFQKDTVFVNHMEEKPYK 242

  Fly   299 ----------------HSTD----KPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFT 343
                            |.|.    ||:.|:.|.|:|.:|.....|.|:||||.|:.|..|.|:|.
Human   243 WNGSEIAFLQMSDLTVHQTSHMEMKPYECSECGKSFCKKSKFIIHQRTHTGEKPYECNQCGKSFC 307

  Fly   344 RKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHM 408
            :|..:..|.|.||||.|:.|:.|.|:|.:|.|.:.|...|:|:.|::|..|||.:.:|.||..|.
Human   308 QKGTLTVHQRTHTGEKPYECNECGKNFYQKLHLIQHQRTHSGEKPYECSYCGKSFCQKTHLTQHQ 372

  Fly   409 RSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPH 473
            |:|:.|.|:.|..|||:||:|....:|...|||...::|..|.|.|.||..|..|:|.||||.|:
Human   373 RTHSGERPYVCHDCGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHLRTHTGEKPY 437

  Fly   474 RCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTF 538
            .|:.|.|.|:|..:|..|.|.|:||.|::|..|.|.|.....::.|.|.||||.|::|..|.|.|
Human   438 ECNECGKFFSRLSYLTVHYRTHSGEKPYECNECGKTFYLNSALMRHQRVHTGEKPYECNECGKLF 502

  Fly   539 TRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNH 603
            ::..:||.|.|.|:|..|:.||.|.|||.:...|..|.|:|.|:.|::|..|.|.|::..:|..|
Human   503 SQLSYLTIHHRTHSGVKPYECSECGKTFYQNSALCRHRRIHKGEKPYECYICGKFFSQMSYLTIH 567

  Fly   604 MRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQ 668
            .|.||.:.|:.|:.|.|.|.:...|..| .|.|||::.:.|..|||.|.....|..|.|.|:.
Human   568 HRIHSGEKPYECSECGKTFCQNSALNRH-QRTHTGEKAYECYECGKCFSQMSYLTIHHRIHSG-- 629

  Fly   669 EMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
              |:||.|.:|.|.|....:|..|.|:||||||:.||.|.|.|..:.....|.:::
Human   630 --EKPFECNECGKAFSRMSYLTVHYRTHSGEKPYECTECGKKFYHKSAFNSHQRIH 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	5/43 (12%)
		C2H2 Zn finger	279..299	CDD:275368	6/39 (15%)
		COG5048	300..723	CDD:227381	171/426 (40%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
ZNF12	NP_057349.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..306	CDD:290200	10/18 (56%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		COG5048	307..683	CDD:227381	152/380 (40%)
		zf-H2C2_2	312..334	CDD:290200	10/21 (48%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-H2C2_2	339..362	CDD:290200	9/22 (41%)
		C2H2 Zn finger	355..375	CDD:275368	9/19 (47%)
		zf-H2C2_2	367..392	CDD:290200	12/24 (50%)
		C2H2 Zn finger	383..403	CDD:275368	8/19 (42%)
		C2H2 Zn finger	439..459	CDD:275368	8/19 (42%)
		zf-H2C2_2	451..474	CDD:290200	10/22 (45%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		zf-H2C2_2	479..504	CDD:290200	11/24 (46%)
		C2H2 Zn finger	495..515	CDD:275368	8/19 (42%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	538..560	CDD:290200	9/21 (43%)
		C2H2 Zn finger	551..571	CDD:275368	7/19 (37%)
		zf-H2C2_2	563..586	CDD:290200	9/22 (41%)
		zf-C2H2	577..599	CDD:278523	7/22 (32%)
		C2H2 Zn finger	579..599	CDD:275368	7/20 (35%)
		zf-H2C2_2	591..616	CDD:290200	11/25 (44%)
		C2H2 Zn finger	607..627	CDD:275368	8/19 (42%)
		zf-H2C2_2	619..644	CDD:290200	11/28 (39%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
		zf-H2C2_2	647..670	CDD:290200	13/22 (59%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860