DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp974

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001360956.1	Gene:	Zfp974 / 73430	MGIID:	1920680	Length:	826	Species:	Mus musculus

Alignment Length:	508	Identity:	189/508 - (37%)
Similarity:	259/508 - (50%)	Gaps:	6/508 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |..|||.|:.|..|:.|::.||:.:||.|:.||:||.....||||..||.|...|.|..|...|.
Mouse   277 CSECGKAFKRRSNLVQHQKTHSDERPFQCKDCGKGFIVLAQLTRHQNIHTGEKSFECHECGKAFR 341

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            ....|.||.|.||.:|||.|..|.|.|...:.|..|...||...||.|:.|.|:|.|..::|.|.
Mouse   342 LPQQLTRHQKSHSGEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLVEHR 406

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            ..|....||:|:.|.|:|.|.:..:.|...|:|:.|.||..|||.:....||..|...||.|..|
Mouse   407 LIHADVKPHKCNECGKAFKRNKSLMQHQKIHSGERPFQCQECGKAFIVLAHLTRHQTIHTGEKSF 471

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            .|:.|||.|....|...|...||||.|..|:.|.|.|..:.:|..|.:.|.......|:.|.|.|
Mouse   472 ECKECGKKFRTATHLVQHQSIHTGEKPFECNVCGKAFRLQIYLSEHQKTHMEAKHFECNICGKVF 536

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            ..:.:|..|.:.||.|.||||..|..||..|..:..|...||.|.|::|..|.|.|.::.:.|:|
Mouse   537 RLQVYLSEHQKTHTEEKPFKCKLCGSAFRSKYQLSKHHTVHTDEKPYQCKECGKCFRQRSNFTDH 601

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            ...|||..|.:|..|.|.:.....|..|.:.|:.:.|::|:.|.|.|.....||||...|:|:.|
Mouse   602 QSIHTGKKPFQCKECGKFYRLNTLLIRHQKSHSSERPYECKECGKAFHLPSELNNHQIVHTSNRP 666

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            ..|.||.|.|.|:..||.||: .|:|.:.:.|:.|||.|..:.:||.|::.|:.    |:||.|:
Mouse   667 FECKVCGKSFKRESTLIQHMA-IHSGVKSYECKECGKGFIHRSSLLHHRKIHSD----EKPFKCQ 726

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAMM 730
            :|.|.|:...:|..|...|:|||...|..|..||..:..|.:|.:: |.|..:
Mouse   727 ECGKAFVVLAYLTRHQSIHTGEKSFECQHCGSAFRYKSQLSKHQRI-HTDVRL 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	9/19 (47%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		COG5048	300..723	CDD:227381	154/422 (36%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Zfp974	NP_001360956.1	KRAB	14..75	CDD:214630
		C2H2 Zn finger	175..195	CDD:275368
		COG5048	199..574	CDD:227381	114/296 (39%)
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..325	CDD:275368	9/19 (47%)
		C2H2 Zn finger	333..353	CDD:275368	7/19 (37%)
		C2H2 Zn finger	361..381	CDD:275368	6/19 (32%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		COG5048	411..781	CDD:227381	134/374 (36%)
		C2H2 Zn finger	417..437	CDD:275368	6/19 (32%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		C2H2 Zn finger	501..521	CDD:275368	6/19 (32%)
		C2H2 Zn finger	529..549	CDD:275368	6/19 (32%)
		C2H2 Zn finger	557..577	CDD:275368	6/19 (32%)
		C2H2 Zn finger	585..605	CDD:275368	6/19 (32%)
		C2H2 Zn finger	613..633	CDD:275368	5/19 (26%)
		C2H2 Zn finger	641..661	CDD:275368	8/19 (42%)
		C2H2 Zn finger	669..689	CDD:275368	10/20 (50%)
		C2H2 Zn finger	697..717	CDD:275368	8/19 (42%)
		C2H2 Zn finger	725..745	CDD:275368	6/19 (32%)
		C2H2 Zn finger	753..773	CDD:275368	6/20 (30%)
		C2H2 Zn finger	781..801	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950