DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp942

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001185977.1	Gene:	Zfp942 / 73233	MGIID:	1920483	Length:	486	Species:	Mus musculus

Alignment Length:	494	Identity:	174/494 - (35%)
Similarity:	238/494 - (48%)	Gaps:	82/494 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 QLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRH 299
            |.|||:....::|             |.....||||                     ::.:.:
Mouse    70 QHIVHKHVTIQKK-------------SYKYYEHGKI---------------------IQEYTQ-- 98

  Fly   300 STDKPFACTICQKTFARKEHLD--NHFRSHTGETPFRCQY--CAKTFTRKEHMVNHVRKHTGETP 360
                   ..:.|..| |..|::  |..|..||.|...|:|  |.........:..:...|.|:..
Mouse    99 -------SVLYQDNF-RDTHVESSNVNRHETGNTREPCKYKNCVNCLNLCSTIGLNQGLHIGKKE 155

  Fly   361 HRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKS 425
            |...:..|.|..|: .:.....::|:.|::|..|.:.:|:|..|..|...||.|.|::|..|.|.
Mouse   156 HNGTVLNKVFDSKQ-ILGLKQTNSGKKPYRCSECSRCFTKKCKLRQHQTIHTGEKPYKCSECDKC 219

  Fly   426 FSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVN 490
            |..|...:.|..:||.|..::|..|.|.||.|..|..|.|.||||.|::||.|.|:||||.:|..
Mouse   220 FFYKYSLSIHQRFHTSEKLYKCSECDKCFTFKSVLRIHQRIHTGEKPYKCSKCEKSFTRKSNLRI 284

  Fly   491 HIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDS 555
            |.|.||||.|:||:.|.|.||.|:....|.|.||||.|:||:.|.|:||||.||..|.|.|||:.
Mouse   285 HQRIHTGEKPYKCSECDKCFTFKNTHRIHQRIHTGEKPYKCSECEKSFTRKSHLRIHQRIHTGEK 349

  Fly   556 PHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNK 620
            |::||.|.|.||.:..|:||.|:|||..|:||..|.|.||||                    ||
Mouse   350 PYKCSECDKCFTYEHTLSNHQRIHTGQKPYKCSECDKCFTRK--------------------CN- 393

  Fly   621 PFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFIC 685
                   ||.| .:.|||::|:.|..|.|.|..||.|..||.:||.    |:|:.|.:|.|.|..
Mouse   394 -------LIIH-QKIHTGEKPYKCSECDKCFTHKGGLSIHQITHTG----EKPYKCSECNKCFTH 446

  Fly   686 KGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            ||.|..|.|.||||||:.|:.|.|.|..:.:|:.|.:::
Mouse   447 KGDLRRHQRIHSGEKPYKCSECDKCFTRKFSLRSHQRIH 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/7 (57%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	164/426 (38%)
		C2H2 Zn finger	307..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	335..355	CDD:275368	3/21 (14%)
		C2H2 Zn finger	363..383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	11/19 (58%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	11/19 (58%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	5/20 (25%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	9/19 (47%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Zfp942	NP_001185977.1	KRAB	15..52	CDD:366587
		C2H2 Zn finger	185..205	CDD:275368	6/19 (32%)
		zf-H2C2_2	198..220	CDD:372612	9/21 (43%)
		C2H2 Zn finger	213..233	CDD:275368	6/19 (32%)
		COG5048	<237..397	CDD:227381	86/187 (46%)
		C2H2 Zn finger	241..261	CDD:275368	9/19 (47%)
		C2H2 Zn finger	269..289	CDD:275368	11/19 (58%)
		C2H2 Zn finger	297..317	CDD:275368	8/19 (42%)
		C2H2 Zn finger	325..345	CDD:275368	11/19 (58%)
		C2H2 Zn finger	353..373	CDD:275368	10/19 (53%)
		C2H2 Zn finger	381..401	CDD:275368	12/48 (25%)
		SFP1	<403..481	CDD:227516	35/81 (43%)
		C2H2 Zn finger	409..429	CDD:275368	9/19 (47%)
		C2H2 Zn finger	437..457	CDD:275368	9/19 (47%)
		C2H2 Zn finger	465..485	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950