DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp74

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_848471.2	Gene:	Zfp74 / 72723	MGIID:	107784	Length:	679	Species:	Mus musculus

Alignment Length:	516	Identity:	207/516 - (40%)
Similarity:	303/516 - (58%)	Gaps:	17/516 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |:.|||.|.....||.|.|.|:..|.:.|..||:||:..:.|..|.|:|.....:.|..|...|.
Mouse   181 CNHCGKGFSQTLDLIRHLRVHTGGKLYECHQCGKGFSHKEKLINHHKLHSREQCYECSECGKTFI 245

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            ..::|.||.:.|:.:||:.|..|.|:|.:|.:|.:|.:.||||.|::|..|.|:|::|:.:|.|.
Mouse   246 KMSNLIRHQRIHTGEKPYVCQECGKSFGQKSNLIDHEKIHTGEKPYKCNECGKSFSQKQSLVAHQ 310

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            :.||||.|:.|:.|.|:|.|......|...|||:.|::||.|||.:::...|..|:|.||.|.|:
Mouse   311 KVHTGEKPYACNECGKAFPRVASLALHMRGHTGEKPYKCDKCGKAFSQFSMLIIHVRVHTGEKPY 375

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            .|..|||:||:....|.||..||||.|:.|..|.|:|:.|::.:.|.:.||.|.|:.|:.|.|.|
Mouse   376 ECGECGKAFSQSSALTVHIRSHTGEKPYECKECRKSFSHKKNFITHQKIHTREKPYGCNECGKAF 440

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            .:..:||.|.|.||||.|:.|..|.|||::|.:::.|.:.|:||.|::|..|.|.|::|::...|
Mouse   441 IQMSNLVRHQRIHTGEKPYLCKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQKQNFITH 505

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            .:.|||:.|:.|:.|.|.|::...||.|:|.|||:.|::||.|.|.|::...||.|||.|:.:.|
Mouse   506 QKVHTGEKPYDCNKCGKAFSQIASLTLHLRSHTGEKPYECEKCGKAFSQCSLLNLHMRSHTGEKP 570

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            :.||.|.|.|:::..||.|| |.|||::|:.|..|||:|....:|..|.|.||.    |:||.|.
Mouse   571 YVCNECGKAFSQRTSLIVHM-RGHTGEKPYECNKCGKAFSQSSSLTIHIRGHTG----EKPFDCS 630

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPH 738
            .|.|.|.....|..|||.|:||||:.|..|.|||.::.:|.||.:            :|.|
Mouse   631 NCGKAFSQISSLTLHMRKHTGEKPYVCIECGKAFSQKSHLVRHQR------------IHTH 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	178/422 (42%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	10/19 (53%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
Zfp74	NP_848471.2	KRAB	8..68	CDD:214630
		C2H2 Zn finger	181..201	CDD:275368	9/19 (47%)
		COG5048	205..638	CDD:227381	178/437 (41%)
		C2H2 Zn finger	209..229	CDD:275368	8/19 (42%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		C2H2 Zn finger	405..425	CDD:275368	6/19 (32%)
		C2H2 Zn finger	433..453	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
		C2H2 Zn finger	545..565	CDD:275368	10/19 (53%)
		C2H2 Zn finger	573..593	CDD:275368	10/20 (50%)
		C2H2 Zn finger	601..621	CDD:275368	8/19 (42%)
		C2H2 Zn finger	629..649	CDD:275368	8/19 (42%)
		zf-H2C2_2	641..666	CDD:372612	14/24 (58%)
		C2H2 Zn finger	657..677	CDD:275368	8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H51861
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17375
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.890