DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp788

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001347603.1	Gene:	Zfp788 / 67607	MGIID:	1914857	Length:	884	Species:	Mus musculus

Alignment Length:	502	Identity:	180/502 - (35%)
Similarity:	254/502 - (50%)	Gaps:	5/502 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |..|||.|:....|..|:..|:|.||:.|..|.:.|.....|..|.::|.|...:.|..|...|.
Mouse   268 CLQCGKAFRNFSSLQKHKIAHTEEKPYKCHYCNKVFICQGSLQSHIRVHTGEKPYECKQCGKAFR 332

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            .|:|..||.|.|:.:||:.|..|.|:|.....|..|.|:|:.|.|:.|:.|.|.|.....:..|.
Mouse   333 VNSSFWRHKKVHTGEKPYECKQCGKSFIYPSLLQTHERTHSAEKPYSCKQCGKAFKSHSSLRVHE 397

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            |.|||:.|:.|..|.:||........|...|:|..|:.|..|||.:.|...|..|.|:||.|.|:
Mouse   398 RNHTGKKPYECKQCGRSFIYPCLLQIHERTHSGVKPYGCKQCGKAFRRLSDLRVHERTHTGEKPY 462

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            .|:.|.|||..:.....|...||||.|::|..|||.|.....|..|.|.||||.|:.|..|.|.|
Mouse   463 ECKQCAKSFINRYLLKMHQKSHTGEKPYKCKICSKAFVYPSLLKLHERSHTGEKPYPCKQCDKAF 527

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            .....|..|.|.||||.|:.|..|.:||...:.:..|.|.||....:.|.:|:|.|..:..|..|
Mouse   528 IFPSLLKLHERTHTGEKPYACKQCGEAFKSYNSLQRHKRIHTDVKAYVCKHCSKAFICQRSLQLH 592

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            .|.|||:.|::|..|..:|.....|..|..:|||.:.::|:.|.::|.....|..|.|.||...|
Mouse   593 NRTHTGEKPYKCEQCGNSFRYHNSLQRHKIIHTGKNLYECKQCDRSFIYPYLLQIHDRTHSGGKP 657

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            :.|..|.|.:.....|..| .|.|:.::|::|:.|||:|....:|..|:|:||.    |:|:.|:
Mouse   658 YECTQCGKSYIYPSLLRIH-ERTHSAEKPYSCKQCGKAFKSHSSLRVHERNHTG----EKPYECK 717

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            :|.::||....|.:|.|.|||.||:.|..|.|||....:.:.|.|::
Mouse   718 QCGRSFIYPCLLQTHERIHSGVKPYECKQCGKAFRGHSSFRVHKKLH 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		COG5048	300..723	CDD:227381	152/422 (36%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Zfp788	NP_001347603.1	KRAB	23..64	CDD:307490
		C2H2 Zn finger	240..260	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		zf-H2C2_2	308..332	CDD:316026	6/23 (26%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	336..361	CDD:316026	11/24 (46%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		C2H2 Zn finger	408..428	CDD:275368	5/19 (26%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	464..484	CDD:275368	6/19 (32%)
		COG5048	488..883	CDD:227381	101/282 (36%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	5/19 (26%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	6/20 (30%)
		C2H2 Zn finger	688..708	CDD:275368	8/19 (42%)
		C2H2 Zn finger	716..736	CDD:275368	7/19 (37%)
		C2H2 Zn finger	744..764	CDD:275368	7/19 (37%)
		C2H2 Zn finger	772..792	CDD:275368
		C2H2 Zn finger	800..820	CDD:275368
		C2H2 Zn finger	828..848	CDD:275368
		C2H2 Zn finger	856..876	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950