DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Gm14326

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001177231.1	Gene:	Gm14326 / 665211	MGIID:	3709298	Length:	554	Species:	Mus musculus

Alignment Length:	487	Identity:	188/487 - (38%)
Similarity:	251/487 - (51%)	Gaps:	6/487 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 HRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDK 303
            |.|..|..:|.....||:.|.......||...|.|.....|..|...|.....|:.|.:.|:.:|
Mouse    65 HERSCSAEQPSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKDFRTWNVLQIHKRTHTGEK 129

  Fly   304 PFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKK 368
            |:.|..|.|.|||..||..|.|:|.||..:.|..|.|.|.|:..:..|.|.||||.|:.|:.|.|
Mouse   130 PYDCKQCGKAFARSCHLRIHNRTHAGEKQYECNQCGKAFKRRSDLQIHKRTHTGEKPYECNQCGK 194

  Fly   369 SFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFT 433
            :|........|...|||:.|::|..|||.:::..||..|.|:||.|.|:....|||:|:|.....
Mouse   195 AFVSSGDLQKHKRTHTGEKPYECKQCGKAFSQSSHLRIHKRTHTGEKPYEWNQCGKAFARSGDLQ 259

  Fly   434 NHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGE 498
            .|...||||.|:.|..|.|.|....||..|.|:|||:.|:.|..|.|.|.....|..|.|.|||:
Mouse   260 KHKRTHTGEKPYECKQCGKAFAHSSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGD 324

  Fly   499 TPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCK 563
            .|::|..|.||||....:..|.:.||||.|::|..|.|.|::..||..|.|.|||:.|:.|:.|.
Mouse   325 KPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCGKAFSQSRHLRIHKRTHTGEKPYECNQCG 389

  Fly   564 KTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHL 628
            |.|.|......|.|.|||:.|::|..|.|.|.|:..|..|.|.|:.:..:.|..|.|.|....||
Mouse   390 KAFARSGDQQEHKRTHTGEKPYECNQCGKAFIRRRVLQIHKRTHTGEKSYECKQCGKAFAGSSHL 454

  Fly   629 INHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHM 693
            ..| .|.|||::|:.|..|||:|..:..|..|:|:||.    |:.:.|::|.|.|.....|..|.
Mouse   455 RIH-KRTHTGEKPYECNQCGKAFITRRVLQIHKRTHTG----EKSYECKQCGKAFASSSDLQKHK 514

  Fly   694 RSHSGEKPHACTLCSKAFVERGNLKRHMKMNH 725
            |:||||||:.|..|.|||.:..:|:.| |..|
Mouse   515 RTHSGEKPYECKQCGKAFAQSSHLRIH-KQTH 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	2/3 (67%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	169/422 (40%)
		C2H2 Zn finger	307..327	CDD:275368	10/19 (53%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Gm14326	NP_001177231.1	KRAB	3..44	CDD:366587
		C2H2 Zn finger	79..97	CDD:275368	5/17 (29%)
		C2H2 Zn finger	105..125	CDD:275368	5/19 (26%)
		COG5048	129..543	CDD:227381	169/419 (40%)
		C2H2 Zn finger	133..153	CDD:275368	10/19 (53%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		C2H2 Zn finger	189..209	CDD:275368	5/19 (26%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		C2H2 Zn finger	441..461	CDD:275368	8/20 (40%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900