DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF649

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_075562.2	Gene:	ZNF649 / 65251	HGNCID:	25741	Length:	505	Species:	Homo sapiens

Alignment Length:	494	Identity:	164/494 - (33%)
Similarity:	225/494 - (45%)	Gaps:	78/494 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 KIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPF 333
            |:..|.|::|             ||..:  ||...|           ..|..|:|.     :.|.
Human    59 KLEQGEPLWT-------------LEDEI--HSPAHP-----------EIEKADDHL-----QQPL 92

  Fly   334 RCQYCAK-TFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEH----------YVNHYMWHTGQT 387
            :.|...| |..|.|| ...::.:.|.|..     .:.:.|||.          :.||     .|.
Human    93 QNQKILKRTGQRYEH-GRTLKSYLGLTNQ-----SRRYNRKEPAEFNGDGAFLHDNH-----EQM 146

  Fly   388 PHQCDV--CGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFC 450
            |.:.:.  ..|..:.|.....|.::|..|....|..|||:|.:|...|.|...|||:.||.|..|
Human   147 PTEIEFPESRKPISTKSQFLKHQQTHNIEKAHECTDCGKAFLKKSQLTEHKRIHTGKKPHVCSLC 211

  Fly   451 SKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDH 515
            .|.|.:|..|..|.|.|.||.||.||.|.|.|.::..|..|.|.|.||.|:.|:.|.|||.||..
Human   212 GKAFYKKYRLTEHERAHRGEKPHGCSLCGKAFYKRYRLTEHERAHKGEKPYGCSECGKAFPRKSE 276

  Fly   516 MVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHT 580
            :..|.|.|||..||:|:.|.:.|:||..|..|.|.|||:.||.||.|.|.|.:|.:|..|.|.||
Human   277 LTEHQRIHTGIKPHQCSECGRAFSRKSLLVVHQRTHTGEKPHTCSECGKGFIQKGNLNIHQRTHT 341

  Fly   581 GDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCE 645
            |:.|:.|..|.|.|::|..|..|.|.|:...|..|..|.:|.::|..||.| .:.|:|::|:.|.
Human   342 GEKPYGCIDCGKAFSQKSCLVAHQRYHTGKTPFVCPECGQPCSQKSGLIRH-QKIHSGEKPYKCS 405

  Fly   646 TCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKA 710
            .|||:|..|..|:.|.|:||.    |||:.|::|.|.:.....||.|.|.||.||
Human   406 DCGKAFLTKTMLIVHHRTHTG----ERPYGCDECEKAYFYMSCLVKHKRIHSREK---------- 456

  Fly   711 FVERGNLKRHMKMNHPDAMMP--PPPVHPHPQIPAGVLT 747
               ||:   .:|:.:|.....  .|..|...:.|..::|
Human   457 ---RGD---SVKVENPSTASHSLSPSEHVQGKSPVNMVT 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	1/1 (100%)
		C2H2 Zn finger	279..299	CDD:275368	2/19 (11%)
		COG5048	300..723	CDD:227381	151/435 (35%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		C2H2 Zn finger	335..355	CDD:275368	6/20 (30%)
		C2H2 Zn finger	363..383	CDD:275368	5/29 (17%)
		C2H2 Zn finger	391..411	CDD:275368	3/21 (14%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	2/17 (12%)
ZNF649	NP_075562.2	KRAB	8..68	CDD:214630	3/8 (38%)
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		zf-H2C2_2	193..215	CDD:290200	10/21 (48%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		COG5048	260..>321	CDD:227381	28/60 (47%)
		C2H2 Zn finger	264..284	CDD:275368	9/19 (47%)
		zf-H2C2_2	276..301	CDD:290200	10/24 (42%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
		zf-H2C2_2	305..329	CDD:290200	13/23 (57%)
		C2H2 Zn finger	320..340	CDD:275368	9/19 (47%)
		zf-H2C2_2	332..357	CDD:290200	11/24 (46%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		C2H2 Zn finger	376..396	CDD:275368	7/20 (35%)
		zf-H2C2_2	389..413	CDD:290200	11/24 (46%)
		C2H2 Zn finger	404..424	CDD:275368	9/19 (47%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..481		8/41 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910