DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp970

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001171039.1	Gene:	Zfp970 / 628308	MGIID:	3652255	Length:	522	Species:	Mus musculus

Alignment Length:	468	Identity:	181/468 - (38%)
Similarity:	250/468 - (53%)	Gaps:	6/468 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 FTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDN 322
            |.||:...|:.:..........|.|...||..:..:||::.|:.:|.:.|..|.|.|..:..|..
Mouse    56 FQTSRSHGRYERRSSAEQHSEFIQCGKAFACQSHSQRHVRIHNGEKHYECNQCGKDFGTRSVLQR 120

  Fly   323 HFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQT 387
            ..|:||||.|:.|.:|.|.|.....:..|.|||||:.|:.|:.|.|:|.::.....|...|||:.
Mouse   121 LKRTHTGEKPYECNHCGKAFAESSTLQIHKRKHTGDEPYECNHCVKAFAKRSDLQIHKRIHTGEK 185

  Fly   388 PHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSK 452
            |::|:.|||.:||..||..|.|:||.|.|:.|:.|||:|:|......|...||||.|:.|..|.|
Mouse   186 PYECNQCGKAFTRSSHLGIHKRTHTGEKPYECKQCGKAFARSSTLQTHKHTHTGEKPYECKQCGK 250

  Fly   453 TFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMV 517
            .|.:...|..|.|.||.|.|:.|..|.|.|.....|..|.|.||||.|::|..|.|||.::..:.
Mouse   251 AFAQSGPLQIHKRTHTAEKPYECKQCGKAFAHSSTLQIHKRTHTGEKPYECKQCDKAFVKRGELQ 315

  Fly   518 NHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGD 582
            .|.|.||||.|::|..|.|.|.:...|..|.|.|||:.|..|:.|.|.|.|...|..|.|.|||:
Mouse   316 IHKRTHTGEKPYECKQCGKAFAQSGTLQEHERTHTGEKPFECNQCGKAFVRCIALRIHERTHTGE 380

  Fly   583 SPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETC 647
            .|::|:.|.|.|.:...|..|.|.|:.:.|..||.|.|.|.:...|..| .|.|||::|:.|:.|
Mouse   381 KPYECKQCGKAFAQSGTLQGHERTHTGEKPFECNQCGKAFVQCIALRIH-ERTHTGEKPYECKQC 444

  Fly   648 GKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFV 712
            ||:|..:..|..|:|:||.    |:|:.|::|.|.|..:..|..|.|:|:||||:.|..|.|||.
Mouse   445 GKAFAHRSTLQIHERTHTG----EKPYECKQCGKAFAHRSTLQIHKRTHTGEKPYECKQCGKAFA 505

  Fly   713 ERGNLKRHMKMNH 725
            ....|:.| |..|
Mouse   506 HSSTLQIH-KRTH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	4/12 (33%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	168/422 (40%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	10/19 (53%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Zfp970	NP_001171039.1	KRAB	4..>45	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	75..477	CDD:227381	159/406 (39%)
		C2H2 Zn finger	79..97	CDD:275368	5/17 (29%)
		C2H2 Zn finger	105..125	CDD:275368	6/19 (32%)
		C2H2 Zn finger	133..153	CDD:275368	6/19 (32%)
		C2H2 Zn finger	161..181	CDD:275368	5/19 (26%)
		zf-H2C2_2	173..198	CDD:290200	9/24 (38%)
		C2H2 Zn finger	189..209	CDD:275368	10/19 (53%)
		zf-H2C2_2	201..226	CDD:290200	13/24 (54%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		zf-H2C2_2	230..254	CDD:290200	10/23 (43%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	258..282	CDD:290200	11/23 (48%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..309	CDD:290200	12/22 (55%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	313..338	CDD:290200	11/24 (46%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	11/23 (48%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	398..422	CDD:290200	10/23 (43%)
		C2H2 Zn finger	413..433	CDD:275368	8/20 (40%)
		zf-H2C2_2	425..450	CDD:290200	12/25 (48%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	11/27 (41%)
		COG5048	465..>522	CDD:227381	22/54 (41%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		zf-H2C2_2	482..506	CDD:290200	13/23 (57%)
		C2H2 Zn finger	497..517	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4265
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840