DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and Rbak

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001038947.1	Gene:	Rbak / 57782	MGIID:	1927369	Length:	711	Species:	Mus musculus

Alignment Length:	583	Identity:	190/583 - (32%)
Similarity:	274/583 - (46%)	Gaps:	89/583 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 ATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTS-----QD---LTRHG----- 268
            ::|.|.|..||:..:...:||.....::..||.||..||:.:..|     ||   .::|.
Mouse   130 SSGAHSCVSCGETLESVSELISSDGSYALEKPSMCFECGKAYGESLEDFNQDEGNSSQHDENILQ 194

  Fly   269 KIHI------------------------------------GGPMFTCIVCFNVFANNTSLERHMK 297
            |:.|                                    .||.|..:..|:.:. .:.:|.
Mouse   195 KVTILEKPFAYECMEALDSESVFMARERAYMGEKPYDWGDSGPDFIQMSDFSTYP-RSQMEL--- 255

  Fly   298 RHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHR 362
                 |||.||.|.|:|.:|.....|.|:||||.|:.|..|.|:|::|..:..|.|.|..|.|::
Mouse   256 -----KPFECTQCGKSFCKKSKFIIHQRAHTGEKPYACSVCGKSFSQKGTLTVHRRSHLEEKPYK 315

  Fly   363 CDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFS 427
            |:.|.|:|.:|.|...|...|:|:.|::|..|||.:.:|.||..|.|:|:.|.|:.|..||||||
Mouse   316 CNECGKTFCQKLHLTQHQRTHSGEKPYECSECGKSFCQKTHLTLHQRNHSGERPYPCNECGKSFS 380

  Fly   428 RKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHI 492
            ||....:|...||||..::|:.|.|::.||..|:.|.|.||||.|::||.|.|.|:|..:|..|.
Mouse   381 RKSALNDHQRTHTGEKLYKCNECGKSYYRKSTLITHQRTHTGEKPYQCSECGKFFSRVSYLTIHY 445

  Fly   493 RQHTGETPFKCTYCTKAFTRKDHMVNHVRQHT--------------------------GESPHKC 531
            |.|..|.|::||.|.|.|......:.|.:.|.                          ||..::|
Mouse   446 RSHLEEKPYECTECGKTFNLNSAFIRHWKVHAEERVQECGECGKPSPLQCAPDHTGDLGEKRYEC 510

  Fly   532 TYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTR 596
            ..|.|||........|.....|:..:.|:.|.|:|:.....|.|.|.|:.:.|..|..|.|||:.
Mouse   511 NECGKTFLDSSAFHRHQSVPEGEKTYECNICGKSFSDSSCYTVHYRGHSEEKPFGCSECGKTFSH 575

  Fly   597 KEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQ 661
            ...|..|.|.|:.:.|:.|..|.|.|::|.:|..| .|.|:|::|:.|..|||.|....||..|.
Mouse   576 NSSLFRHQRVHTGEKPYECYECGKFFSQKSYLTIH-HRIHSGEKPYECSKCGKVFSRMSNLTVHY 639

  Fly   662 RSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            |||:.    |:|:.|.:|.|.|..|.:|..|.|:||||||:.|..|.|.|..|.....|.:::
Mouse   640 RSHSG----EKPYECNECGKVFSQKSYLTVHYRTHSGEKPYECNECGKKFHHRSAFNSHQRIH 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	8/32 (25%)
		C2H2 Zn finger	279..299	CDD:275368	2/19 (11%)
		COG5048	300..723	CDD:227381	166/448 (37%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Rbak	NP_001038947.1	KRAB	8..68	CDD:214630
		Required for interaction with RB1. /evidence=ECO:0000250	170..257		11/95 (12%)
		C2H2 Zn finger	260..280	CDD:275368	8/19 (42%)
		C2H2 Zn finger	288..308	CDD:275368	7/19 (37%)
		zf-C2H2	314..336	CDD:306579	7/21 (33%)
		C2H2 Zn finger	316..336	CDD:275368	7/19 (37%)
		COG5048	340..699	CDD:227381	131/364 (36%)
		C2H2 Zn finger	344..364	CDD:275368	9/19 (47%)
		C2H2 Zn finger	372..392	CDD:275368	10/19 (53%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		Interaction with AR. /evidence=ECO:0000250	414..711		98/290 (34%)
		C2H2 Zn finger	428..448	CDD:275368	9/19 (47%)
		C2H2 Zn finger	456..476	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
		C2H2 Zn finger	566..586	CDD:275368	8/19 (42%)
		C2H2 Zn finger	594..614	CDD:275368	8/20 (40%)
		C2H2 Zn finger	622..642	CDD:275368	9/19 (47%)
		C2H2 Zn finger	650..670	CDD:275368	8/19 (42%)
		C2H2 Zn finger	678..698	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810