DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF492

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_065906.1	Gene:	ZNF492 / 57615	HGNCID:	23707	Length:	531	Species:	Homo sapiens

Alignment Length:	505	Identity:	179/505 - (35%)
Similarity:	265/505 - (52%)	Gaps:	35/505 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 PIATGTHVCDICGKMFQFRY-QLIVHRRY------HSERKPFM-----CQV---CGQG----FTT 260
            |:.......|:..|..:..| |.::.|||      :.:.:.:.     |:|   |..|    .||
Human    43 PVVCSYFARDLWPKQGKKNYFQKVILRRYKKCGCENLQLRKYCKSMDECKVHKECYNGLNQCLTT 107

  Fly   261 SQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFR 325
            :|:           .:|.|.....||...::..||..||:..|.|.|..|:|:|....||..|.|
Human   108 TQN-----------KIFQCDKYVKVFHKFSNSNRHTIRHTGKKSFKCKECEKSFCMLSHLAQHKR 161

  Fly   326 SHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQ 390
            .|:||.|::|:.|.|.:....::..|.|.|||:.|::|:.|.|:|.|..|...|.:.|||:.|::
Human   162 IHSGEKPYKCKECGKAYNETSNLSTHKRIHTGKKPYKCEECGKAFNRLSHLTTHKIIHTGKKPYK 226

  Fly   391 CDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFT 455
            |:.|||.:.:..:|..|.|.||.|.|::||.||::||:....|.|.:.|.||.|::|:.|.|.|:
Human   227 CEECGKAFNQSANLTTHKRIHTGEKPYKCEECGRAFSQSSTLTAHKIIHAGEKPYKCEECGKAFS 291

  Fly   456 RKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHV 520
            :...|..|...||||..::|..|.|.|::..||..|.|.|:||.|:||..|.|||.:...:..|.
Human   292 QSSTLTTHKIIHTGEKFYKCEECGKAFSQLSHLTTHKRIHSGEKPYKCEECGKAFKQSSTLTTHK 356

  Fly   521 RQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPH 585
            |.|.||..:||..|:|.|:|..|||.|.|.|||:.|::|..|.|.|.....||.|..:|||:.|:
Human   357 RIHAGEKFYKCEVCSKAFSRFSHLTTHKRIHTGEKPYKCEECGKAFNLSSQLTTHKIIHTGEKPY 421

  Fly   586 KCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKS 650
            |||.|.|.|.:...|:.|...|:.:.|:....|.|.|.:..||..| ...|||::|:.||.|||:
Human   422 KCEECGKAFNQSSTLSKHKVIHTGEKPYKYEECGKAFNQSSHLTTH-KMIHTGEKPYKCEECGKA 485

  Fly   651 FPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEK 700
            |.....|..|:..|| |:::.:|.:|.....| |.|  :..:.|:.:|||
Human   486 FNNSSILNRHKMIHT-GEKLYKPESCNNACDN-IAK--ISKYKRNCAGEK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/26 (27%)
		C2H2 Zn finger	251..271	CDD:275368	7/26 (27%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	156/401 (39%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	10/19 (53%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF492	NP_065906.1	KRAB	<1..32	CDD:214630
		COG5048	138..522	CDD:227381	152/388 (39%)
		C2H2 Zn finger	143..163	CDD:275368	8/19 (42%)
		zf-H2C2_2	155..179	CDD:290200	11/23 (48%)
		C2H2 Zn finger	171..191	CDD:275368	5/19 (26%)
		zf-H2C2_2	183..208	CDD:290200	10/24 (42%)
		C2H2 Zn finger	199..219	CDD:275368	7/19 (37%)
		zf-H2C2_2	211..236	CDD:290200	10/24 (42%)
		C2H2 Zn finger	227..247	CDD:275368	7/19 (37%)
		zf-H2C2_2	239..264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	255..275	CDD:275368	8/19 (42%)
		C2H2 Zn finger	283..303	CDD:275368	6/19 (32%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		zf-H2C2_2	323..348	CDD:290200	14/24 (58%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	367..387	CDD:275368	10/19 (53%)
		zf-H2C2_2	379..403	CDD:290200	12/23 (52%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	408..432	CDD:290200	13/23 (57%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/20 (30%)
		zf-H2C2_2	463..488	CDD:290200	13/25 (52%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900