DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and ZNF471

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_065864.2	Gene:	ZNF471 / 57573	HGNCID:	23226	Length:	626	Species:	Homo sapiens

Alignment Length:	505	Identity:	186/505 - (36%)
Similarity:	271/505 - (53%)	Gaps:	36/505 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 GTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCG-------------------QGFTTSQDL 264
            |:|      :||. :.::|.|:...::...|.....|                   :.|:.:..:
Human   136 GSH------EMFS-KKEIITHKETITKETEFKYTKFGKCIHLENIEESIYNHTSDKKSFSKNSMV 193

  Fly   265 TRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTG 329
            .:|.|:::|..:|.|..|...|.:::||..|.:.|:.:||:||..|.|.|.:::||..|.|:|||
Human   194 IKHKKVYVGKKLFKCNECDKTFTHSSSLTVHFRIHTGEKPYACEECGKAFKQRQHLAQHHRTHTG 258

  Fly   330 ETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVC 394
            |..|.|:.|.|.|.:.||::.|.|.||||.|::|..|:|:|.:..|...|...|||:.|::|..|
Human   259 EKLFECKECRKAFKQSEHLIQHQRIHTGEKPYKCKECRKAFRQPAHLAQHQRIHTGEKPYECKEC 323

  Fly   395 GKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILW---HTGETPHRCDFCSKTFTR 456
            ||.::.....|.|.|.||.:.|:.|..|||:|.....|..|  |   ||||.|..|..|.|.|:.
Human   324 GKAFSDGSSFARHQRCHTGKRPYECIECGKAFRYNTSFIRH--WRSYHTGEKPFNCIDCGKAFSV 386

  Fly   457 KEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVR 521
            ...|:.|.|.||||.|::|..|.|||:.......|.|.||||.|::|..|.|.|:....:..|.|
Human   387 HIGLILHRRIHTGEKPYKCGVCGKTFSSGSSRTVHQRIHTGEKPYECDICGKDFSHHASLTQHQR 451

  Fly   522 QHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHK 586
            .|:||.|::|..|.|.|.:..||.:|:|.|||:.|:.|..|.|.|.....|..|.|:|||:.|::
Human   452 VHSGEKPYECKECGKAFRQNVHLVSHLRIHTGEKPYECKECGKAFRISSQLATHQRIHTGEKPYE 516

  Fly   587 CEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSF 651
            |..|...|.::.||..|.:.|:.:.|:.||.|.|.|::..:|..| .|.|||::|:.|..|||:|
Human   517 CIECGNAFKQRSHLAQHQKTHTGEKPYECNECGKAFSQTSNLTQH-QRIHTGEKPYKCTECGKAF 580

  Fly   652 PLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKP 701
            ....:...|||.|| ||   ||:.|.:|.|.|..|..|:.|.|||:||:|
Human   581 SDSSSCAQHQRLHT-GQ---RPYQCFECGKAFRRKLSLICHQRSHTGEEP 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	251..271	CDD:275368	4/38 (11%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	166/405 (41%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/22 (36%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF471	NP_065864.2	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	203..610	CDD:227381	165/413 (40%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		zf-H2C2_2	220..245	CDD:290200	11/24 (46%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		zf-H2C2_2	248..273	CDD:290200	13/24 (54%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		zf-H2C2_2	276..301	CDD:290200	12/24 (50%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		zf-H2C2_2	304..328	CDD:290200	10/23 (43%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		zf-H2C2_2	332..357	CDD:290200	11/24 (46%)
		C2H2 Zn finger	348..366	CDD:275368	7/19 (37%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	393..414	CDD:290200	12/20 (60%)
		C2H2 Zn finger	405..425	CDD:275368	7/19 (37%)
		zf-H2C2_2	420..442	CDD:290200	11/21 (52%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		zf-H2C2_2	445..470	CDD:290200	10/24 (42%)
		C2H2 Zn finger	461..481	CDD:275368	8/19 (42%)
		zf-H2C2_2	473..496	CDD:290200	11/22 (50%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		zf-H2C2_2	502..526	CDD:290200	10/23 (43%)
		C2H2 Zn finger	517..537	CDD:275368	6/19 (32%)
		zf-H2C2_2	529..554	CDD:290200	10/24 (42%)
		C2H2 Zn finger	545..565	CDD:275368	8/20 (40%)
		zf-H2C2_2	557..581	CDD:290200	11/24 (46%)
		C2H2 Zn finger	573..593	CDD:275368	8/19 (42%)
		C2H2 Zn finger	601..621	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860