DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF287

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001333096.1	Gene:	ZNF287 / 57336	HGNCID:	13502	Length:	761	Species:	Homo sapiens

Alignment Length:	456	Identity:	169/456 - (37%)
Similarity:	256/456 - (56%)	Gaps:	13/456 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 PMFTCIVCFNVFANNTSLERH---MKRHSTDKPFACTICQKTFARKEHLDN---HFRSHTGETPF 333
            |...|:..::::.||  .|:|   :.:..|......::..:..|...|:..   |.:...||.|:
Human   306 PTEECLSKYDIYRNN--FEKHSNLIVQFDTQLDNKTSVYNEGRATFNHVSYGIVHRKILPGEKPY 368

  Fly   334 RCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKY 398
            :|..|.|.|.:...::.|...|..|..:.|:.|.|.|......:.|...|||:.|::|..|||.:
Human   369 KCNVCGKKFRKYPSLLKHQSTHAKEKSYECEECGKEFRHISSLIAHQRMHTGEKPYECHQCGKAF 433

  Fly   399 TRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNH 463
            :::.||..|.|.||.|.|::|:.|||.||::.|.|.|...||||.|::|..|.|||:....|:||
Human   434 SQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINH 498

  Fly   464 VRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESP 528
            .|.||||.|:.|:.|.|||::..||:.|.:.|||:.|:||..|.|.|::..:::.|.|.|:||..
Human   499 QRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKC 563

  Fly   529 HKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKT 593
            :||..|.|.|.....|..|...|||:..:.|:.|.|.|::..:||.|.|.|||:.|:||..|.|.
Human   564 YKCNECGKAFAHSSTLIQHQTTHTGEKSYICNICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKA 628

  Fly   594 FTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLL 658
            |::..||..|.|.|:.:.|..||:|.|.:.:..:|..| .|.|||::|:.|..|||:|....:|.
Human   629 FSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQH-QRIHTGEKPYKCNECGKAFIYSSSLN 692

  Fly   659 FHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKM 723
            .|||:||.    |||:.|.:|.|:|..:..|:.|.|.|:||||:||.:|.|.|.:..||.:|.::
Human   693 QHQRTHTG----ERPYKCNECDKDFSQRTCLIQHQRIHTGEKPYACRICGKTFTQSTNLIQHQRV 753

  Fly   724 N 724
            :
Human   754 H 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	5/22 (23%)
		COG5048	300..723	CDD:227381	163/425 (38%)
		C2H2 Zn finger	307..327	CDD:275368	3/22 (14%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF287	NP_001333096.1	SCAN	46..144	CDD:413396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..154
		KRAB	170..227	CDD:214630
		SFP1	<364..419	CDD:227516	15/54 (28%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		C2H2 Zn finger	398..418	CDD:275368	5/19 (26%)
		COG5048	422..755	CDD:227381	141/338 (42%)
		C2H2 Zn finger	426..446	CDD:275368	8/19 (42%)
		C2H2 Zn finger	454..474	CDD:275368	9/19 (47%)
		C2H2 Zn finger	482..502	CDD:275368	9/19 (47%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..558	CDD:275368	6/19 (32%)
		C2H2 Zn finger	566..586	CDD:275368	6/19 (32%)
		C2H2 Zn finger	594..614	CDD:275368	8/19 (42%)
		C2H2 Zn finger	622..642	CDD:275368	8/19 (42%)
		C2H2 Zn finger	650..670	CDD:275368	7/20 (35%)
		C2H2 Zn finger	678..698	CDD:275368	9/19 (47%)
		C2H2 Zn finger	706..726	CDD:275368	7/19 (37%)
		C2H2 Zn finger	734..754	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.150