DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and MYNN

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	283	Identity:	100/283 - (35%)
Similarity:	148/283 - (52%)	Gaps:	31/283 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 VRQHTGESPHRCSYCMKTFTRKEHLVNHI--------RQHTGE---------TPFKCTYCTKAFT 511
            |::..|:|...|:.       |||.:::|        .:::||         .|. |..|.|.|:
Human   256 VKRKRGKSQPNCAL-------KEHSMSNIASVKSPYEAENSGEELDQRYSKAKPM-CNTCGKVFS 312

  Fly   512 RKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHV 576
            ....:..|:|.|.|..|:.|..|.|.||:...|..|||.|||:.|::|..|.|.|.:|..|..|.
Human   313 EASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHS 377

  Fly   577 RLHTG-DSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDR 640
            |:|.| :.|:||:.|...|....:|..|.|:||.:.|:.|:.|.:.|.:...|..|:.| |||::
Human   378 RMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRR-HTGEK 441

  Fly   641 PFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACT 705
            |:.|:||||:|.:..:|:.|.|.||.    |:|:.|..|.|:||..|.|..|.|||:||:|..|.
Human   442 PYVCDTCGKAFAVSSSLITHSRKHTG----EKPYICGICGKSFISSGELNKHFRSHTGERPFICE 502

  Fly   706 LCSKAFVERGNLKRHMKMNHPDA 728
            ||..::.:..|||:|....|..|
Human   503 LCGNSYTDIKNLKKHKTKVHSGA 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	98/276 (36%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368
		C2H2 Zn finger	363..383	CDD:275368
		C2H2 Zn finger	391..411	CDD:275368
		C2H2 Zn finger	419..439	CDD:275368
		C2H2 Zn finger	447..467	CDD:275368	1/2 (50%)
		C2H2 Zn finger	475..495	CDD:275368	5/27 (19%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	9/19 (47%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
MYNN	NP_001172047.1	BTB	14..115	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197
		Nuclear localization signal. /evidence=ECO:0000255	174..190
		Nuclear localization signal. /evidence=ECO:0000255	257..262		0/4 (0%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		zf-C2H2	304..324	CDD:306579	6/19 (32%)
		zf-H2C2_2	316..341	CDD:316026	9/24 (38%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)
		zf-H2C2_2	345..369	CDD:316026	12/23 (52%)
		SFP1	<354..438	CDD:227516	29/84 (35%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	6/20 (30%)
		zf-H2C2_2	430..453	CDD:316026	12/23 (52%)
		SFP1	<439..522	CDD:227516	36/86 (42%)
		C2H2 Zn finger	445..465	CDD:275368	9/19 (47%)
		C2H2 Zn finger	473..493	CDD:275368	9/19 (47%)
		C2H2 Zn finger	501..522	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010