DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF83

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001099019.1	Gene:	ZNF83 / 55769	HGNCID:	13158	Length:	516	Species:	Homo sapiens

Alignment Length:	530	Identity:	193/530 - (36%)
Similarity:	268/530 - (50%)	Gaps:	46/530 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 ELLMPKMEGGIHGVDGSGNGGNGGGQNVALAPDGTPIATGTHV-----CDICGKMFQFRYQLIVH 239
            ||.:.:.||.|:..|......|  ..::...|........||:     |:....:|
Human    27 ELQLFQAEGKIYKYDHMEKSVN--SSSLVSPPQRISSTVKTHISHTYECNFVDSLF--------- 80

  Fly   240 RRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKP 304
                                     |:..|.:||...:.|......|........|...|:.:..
Human    81 -------------------------TQKEKANIGTEHYKCSERGKAFHQGLHFTIHQIIHTKETQ 120

  Fly   305 FACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKS 369
            |.|.||.|.|.:|.:|.:|.|.||||.|::|..|.|.|....|:..|.|.||||.|::|:.|.|.
Human   121 FKCDICGKIFNKKSNLASHQRIHTGEKPYKCNECGKVFHNMSHLAQHRRIHTGEKPYKCNECGKV 185

  Fly   370 FTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTN 434
            |.:..|...|...|||:.|::|:.|||.:.:..|||.|...||.|.|:.|..|||.|||..:...
Human   186 FNQISHLAQHQRIHTGEKPYKCNECGKVFHQISHLAQHRTIHTGEKPYECNKCGKVFSRNSYLVQ 250

  Fly   435 HILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGET 499
            |::.||||.|:||:.|.|.|....||..|.|.||||.|::|:.|.|.|:.|..||||.|.||||.
Human   251 HLIIHTGEKPYRCNVCGKVFHHISHLAQHQRIHTGEKPYKCNECGKVFSHKSSLVNHWRIHTGEK 315

  Fly   500 PFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKK 564
            |:||..|.|.|:.|..:|||.|.||||.|:||..|.|.|:|..:|..|:..|.|:.|::|..|.|
Human   316 PYKCNECGKVFSHKSSLVNHWRIHTGEKPYKCNECGKVFSRNSYLAQHLIIHAGEKPYKCDECDK 380

  Fly   565 TFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLI 629
            .|::..||..|.|:|||:.|:||:.|.|.|::..:|..|.|.|:.:..:.||.|.|.|.....|.
Human   381 AFSQNSHLVQHHRIHTGEKPYKCDECGKVFSQNSYLAYHWRIHTGEKAYKCNECGKVFGLNSSLA 445

  Fly   630 NHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMR 694
            :| .:.|||::||.|..|||:|.::.:|..|...||.    |:.|.|.:|.|.|....:||.|.|
Human   446 HH-RKIHTGEKPFKCNECGKAFSMRSSLTNHHAIHTG----EKHFKCNECGKLFRDNSYLVRHQR 505

  Fly   695 SHSGEKPHAC 704
            .|:|:|.:.|
Human   506 FHAGKKSNTC 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	2/19 (11%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	173/405 (43%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	1/1 (100%)
ZNF83	NP_001099019.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		C2H2 Zn finger	95..115	CDD:275368	3/19 (16%)
		COG5048	117..507	CDD:227381	169/394 (43%)
		C2H2 Zn finger	123..143	CDD:275368	9/19 (47%)
		C2H2 Zn finger	151..171	CDD:275368	7/19 (37%)
		C2H2 Zn finger	179..199	CDD:275368	6/19 (32%)
		C2H2 Zn finger	207..227	CDD:275368	8/19 (42%)
		C2H2 Zn finger	235..255	CDD:275368	8/19 (42%)
		C2H2 Zn finger	263..283	CDD:275368	8/19 (42%)
		C2H2 Zn finger	291..311	CDD:275368	10/19 (53%)
		C2H2 Zn finger	319..339	CDD:275368	9/19 (47%)
		C2H2 Zn finger	347..367	CDD:275368	7/19 (37%)
		C2H2 Zn finger	375..395	CDD:275368	8/19 (42%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		C2H2 Zn finger	431..451	CDD:275368	7/20 (35%)
		C2H2 Zn finger	459..479	CDD:275368	7/19 (37%)
		C2H2 Zn finger	487..507	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.050