DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	281	Identity:	87/281 - (30%)
Similarity:	133/281 - (47%)	Gaps:	46/281 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 KTFTRKEHMV---NHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRK 401
            |...||...|   :.::|.....|.....|:.|....|.          :||.|..:..:.:..:
Human   436 KALQRKSRGVYWHSELQKGLESEPTSRRQCRNSPGESEE----------KTPSQEKMSHQSFCAR 490

  Fly   402 EHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHR----------CDFCSKTFTR 456
            :....|:            :|||:.|:..|           :||:          |..|.|||:|
Human   491 DKACTHI------------LCGKNCSQSVH-----------SPHKPALKLEKVSQCPECGKTFSR 532

  Fly   457 KEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVR 521
            ..:|:.|.|.||||.||:||.|.|.|:.:.:|..|:|.||||.|::|..|.|:|.:...::.|.|
Human   533 SSYLVRHQRIHTGEKPHKCSECGKGFSERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQR 597

  Fly   522 QHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHK 586
            .||||.|::|..|.|.|......:.|.|.|||:||::|:.|.|.|....|.:.|.:.|||:.|::
Human   598 THTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTHTGEKPYR 662

  Fly   587 CEYCQKTFTRKEHLNNHMRQH 607
            |.:|::.||:...|..|...|
Human   663 CSHCERGFTKNSALTRHQTVH 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	87/281 (31%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368	4/17 (24%)
		C2H2 Zn finger	363..383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	391..411	CDD:275368	1/19 (5%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		8/40 (20%)
		COG5048	<455..668	CDD:227381	77/245 (31%)
		zf-C2H2	522..543	CDD:278523	9/20 (45%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	535..559	CDD:290200	13/23 (57%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
		zf-H2C2_2	563..588	CDD:290200	12/24 (50%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		zf-H2C2_2	591..616	CDD:290200	11/24 (46%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	623..644	CDD:290200	11/20 (55%)
		C2H2 Zn finger	635..655	CDD:275368	6/19 (32%)
		zf-H2C2_2	647..671	CDD:290200	8/23 (35%)
		zf-C2H2	661..683	CDD:278523	6/21 (29%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100