DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF586

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_060122.2	Gene:	ZNF586 / 54807	HGNCID:	25949	Length:	402	Species:	Homo sapiens

Alignment Length:	350	Identity:	128/350 - (36%)
Similarity:	183/350 - (52%)	Gaps:	22/350 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 HTGE---TPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSF--------TRKEHYVNHY 380
            |.||   .|.:...|.       |:......|:||.|:.|...:|.|        .|::|  .|.
Human    58 HGGEDEAAPSKQSTCI-------HIYKDQGGHSGERPYECGEYRKLFKNKSCLTEPRRDH--KHR 113

  Fly   381 MWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPH 445
            ...||:.|::|...||.:.:|..|..|.|.||.:..:.|..|||||.:..........||.|.|:
Human   114 NVRTGERPYECSKYGKLFHQKPTLHIHERFHTGQKTYECSECGKSFHQSSSLLQRQTLHTRERPY 178

  Fly   446 RCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAF 510
            .|..|.|.|..|..|:||.:.|:|...:.|:.|.|:|.....|:.|.|.||||.|::|:.|.::|
Human   179 ECIECGKAFAEKSSLINHRKVHSGAKRYECNECGKSFAYTSSLIKHRRIHTGERPYECSECGRSF 243

  Fly   511 TRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNH 575
            .....::.|:|.||||.|::|..|.|:|.|...|..|.|.||.:.|:.||.|.|:|:.:.:|.:|
Human   244 AENSSLIKHLRVHTGERPYECVECGKSFRRSSSLLQHQRVHTRERPYECSECGKSFSLRSNLIHH 308

  Fly   576 VRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDR 640
            .|:|||:. |:|..|.|:|:||..|..|:|.|:.:.|:.|:.|.|.|.....||.|: |.|||:|
Human   309 QRVHTGER-HECGQCGKSFSRKSSLIIHLRVHTGERPYECSDCGKSFAENSSLIKHL-RVHTGER 371

  Fly   641 PFTCETCGKSFPLKGNLLFHQRSHT 665
            |:.|..|||||....:...|||.||
Human   372 PYECIDCGKSFRHSSSFRRHQRVHT 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	127/349 (36%)
		C2H2 Zn finger	307..327	CDD:275368	127/349 (36%)
		C2H2 Zn finger	335..355	CDD:275368	2/19 (11%)
		C2H2 Zn finger	363..383	CDD:275368	6/27 (22%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF586	NP_060122.2	KRAB	15..>56	CDD:214630
		KRAB	15..54	CDD:279668
		C2H2 Zn finger	90..116	CDD:275368	6/27 (22%)
		COG5048	<104..366	CDD:227381	98/265 (37%)
		C2H2 Zn finger	124..144	CDD:275368	7/19 (37%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	220..244	CDD:290200	10/23 (43%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		zf-H2C2_2	248..273	CDD:290200	11/24 (46%)
		C2H2 Zn finger	264..284	CDD:275368	8/19 (42%)
		zf-H2C2_2	276..300	CDD:290200	10/23 (43%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
		C2H2 Zn finger	319..339	CDD:275368	9/19 (47%)
		zf-H2C2_2	331..355	CDD:290200	8/23 (35%)
		C2H2 Zn finger	347..367	CDD:275368	8/20 (40%)
		zf-H2C2_2	359..384	CDD:290200	15/25 (60%)
		C2H2 Zn finger	375..395	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910