DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF44

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001157748.1	Gene:	ZNF44 / 51710	HGNCID:	13110	Length:	663	Species:	Homo sapiens

Alignment Length:	504	Identity:	172/504 - (34%)
Similarity:	248/504 - (49%)	Gaps:	34/504 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 CGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNT 290
            |||...:|:......|.|:.:||:.|:.||:.|::..:|.||..:. ||
Human   194 CGKGLSYRHSFQTCERPHTGKKPYDCKECGKTFSSPGNLRRHMVVK-GG---------------- 241

  Fly   291 SLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKH 355
                       |.|:.|.:|.|.|.....|..|.|:||||.|:.|:.|:|.|......:.|.:.|
Human   242 -----------DGPYKCELCGKAFFWPSLLRMHERTHTGEKPYECKQCSKAFPVYSSYLRHEKIH 295

  Fly   356 TGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCE 420
            |||.|:.|..|.|:|.....|:.|...|||:.|::|..|||.::....|..|.|.||.|.|:.|:
Human   296 TGEKPYECKQCSKAFPDYSSYLRHERTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCK 360

  Fly   421 ICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRK 485
            .|||:|.....|..|::.|:|:.||:|..|.|.|........|...||.|.|:.|..|.|..:.:
Human   361 QCGKAFCHLGSFQRHMIMHSGDGPHKCKICGKGFDFPGSARIHEGTHTLEKPYECKQCGKLLSHR 425

  Fly   486 EHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQ 550
            .....|:..|||:.|.|||.|.|||........|.|.||||.|::|..|.|.|.....|..|...
Human   426 SSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGKAFRTSSSLRKHETT 490

  Fly   551 HTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCC 615
            |||:.|::|. |.|.|:......:|...|:.:.|::|:.|.|.|:..::...|.|.||.:..:.|
Human   491 HTGEQPYKCK-CGKAFSDLFSFQSHETTHSEEEPYECKECGKAFSSFKYFCRHERTHSEEKSYEC 554

  Fly   616 NVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCP 680
            .:|.|.|:|..:|..| .|.||.::|:.|:.|.|:|.....||.|:|:||.    |||:.|:.|.
Human   555 QICGKAFSRFSYLKTH-ERTHTAEKPYECKQCRKAFFWPSFLLRHERTHTG----ERPYECKHCG 614

  Fly   681 KNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAM 729
            |.|........|.|:|:||||:.|..|.|||....:..||.:.:..|.:
Human   615 KAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHKRTHWKDIL 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/16 (31%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	154/422 (36%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	4/19 (21%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF44	NP_001157748.1	KRAB	52..88	CDD:279668
		KRAB	52..>88	CDD:214630
		C2H2 Zn finger	192..211	CDD:275368	5/16 (31%)
		C2H2 Zn finger	219..239	CDD:275368	7/19 (37%)
		COG5048	244..655	CDD:227381	152/416 (37%)
		C2H2 Zn finger	247..267	CDD:275368	7/19 (37%)
		zf-H2C2_2	260..282	CDD:290200	11/21 (52%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		zf-H2C2_2	290..310	CDD:290200	9/19 (47%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		zf-H2C2_2	318..339	CDD:290200	9/20 (45%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		zf-H2C2_2	343..366	CDD:290200	11/22 (50%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		zf-H2C2_2	456..480	CDD:290200	11/23 (48%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		C2H2 Zn finger	499..518	CDD:275368	5/19 (26%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		C2H2 Zn finger	554..574	CDD:275368	8/20 (40%)
		zf-H2C2_2	566..589	CDD:290200	9/23 (39%)
		C2H2 Zn finger	582..602	CDD:275368	8/19 (42%)
		zf-H2C2_2	595..619	CDD:290200	13/27 (48%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		zf-H2C2_2	624..647	CDD:290200	12/22 (55%)
		C2H2 Zn finger	638..658	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810