DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and ZNF716

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001152751.1	Gene:	ZNF716 / 441234	HGNCID:	32458	Length:	495	Species:	Homo sapiens

Alignment Length:	400	Identity:	146/400 - (36%)
Similarity:	193/400 - (48%)	Gaps:	36/400 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 QLIVHRRYHSERKPFMCQVCGQGFTTSQDL--------TRHGKIHIGGPMFT--CI--------- 280
            |.::.|||..         |||     :||        ....::|.||..:.  |:
Human   108 QKVILRRYGK---------CGQ-----EDLQVKKCCKSVGECEVHKGGYNYVNQCLSATQNKTFQ 158

  Fly   281 --VCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFT 343
              .|..||...::..||..||:..|.|.|....|:|.....|:.|...||.|..::|:.|.|:|.
Human   159 THKCVKVFGKFSNSNRHKTRHTGKKHFKCKNDGKSFCMLSRLNQHQIIHTREKSYKCEECGKSFN 223

  Fly   344 RKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHM 408
            ....:..|.|.||||.|:||:.|.|:|:.......|...|||:.|:.|:..||.::|.. |.|:.
Human   224 CSSTLTRHKRIHTGEKPYRCEECGKAFSWSASLTKHKRIHTGEKPYTCEERGKVFSRST-LTNYK 287

  Fly   409 RSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPH 473
            |.||.|.|:.||.|||:|||....|||...||||.|::|:.|.|.|:....|..|...||||..:
Human   288 RIHTGEKPYTCEECGKAFSRSSTLTNHKRIHTGERPYKCEECGKAFSLSSTLKKHKIVHTGEKLY 352

  Fly   474 RCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTF 538
            .|..|.|.||....|..|.|.||||.|:.|..|.|||:.......|.|.||||.|:||..|.|.|
Human   353 TCEECGKAFTFSSTLNTHKRIHTGEKPYTCEECGKAFSLPSTFTYHKRTHTGEKPYKCEECGKAF 417

  Fly   539 TRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNH 603
            .....|..|...|||:..::|..|.|.||....|..|.|:|||:.|:|||.|.:||.....|.||
Human   418 NCSSTLKKHKIIHTGEKLYKCKECGKAFTFSSTLNTHKRIHTGEKPYKCEECDQTFKWHSSLANH 482

  Fly   604 MRQHSSDNPH 613
            ...|:.:.|:
Human   483 KNMHTGEKPY 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	3/7 (43%)
		C2H2 Zn finger	251..271	CDD:275368	5/27 (19%)
		C2H2 Zn finger	279..299	CDD:275368	6/30 (20%)
		COG5048	300..723	CDD:227381	126/313 (40%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	11/19 (58%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF716	NP_001152751.1	KRAB	16..76	CDD:214630
		KRAB	16..55	CDD:279668
		C2H2 Zn finger	160..179	CDD:275368	5/18 (28%)
		C2H2 Zn finger	187..207	CDD:275368	5/19 (26%)
		COG5048	211..>494	CDD:227381	116/282 (41%)
		C2H2 Zn finger	215..235	CDD:275368	6/19 (32%)
		zf-H2C2_2	228..251	CDD:290200	11/22 (50%)
		C2H2 Zn finger	243..263	CDD:275368	5/19 (26%)
		zf-H2C2_2	283..307	CDD:290200	13/23 (57%)
		C2H2 Zn finger	298..318	CDD:275368	11/19 (58%)
		zf-H2C2_2	311..334	CDD:290200	11/22 (50%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		CpXC	353..>398	CDD:291051	18/44 (41%)
		C2H2 Zn finger	354..374	CDD:275368	8/19 (42%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	398..419	CDD:290200	12/20 (60%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		zf-H2C2_2	423..446	CDD:290200	8/22 (36%)
		C2H2 Zn finger	438..458	CDD:275368	8/19 (42%)
		zf-H2C2_2	451..474	CDD:290200	12/22 (55%)
		C2H2 Zn finger	466..486	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900