DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and Zfp985

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001014419.2	Gene:	Zfp985 / 433804	MGIID:	3651986	Length:	519	Species:	Mus musculus

Alignment Length:	488	Identity:	177/488 - (36%)
Similarity:	236/488 - (48%)	Gaps:	59/488 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 QLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIG---------GPMFTCIVC-------- 282
            |.|||...:.:.|........:....|...|.:...|..         .|..|..||
Mouse    70 QYIVHEHMNIQEKSSKWDKLSKVLLDSPQYTPYKTYHSSLQYWNQKRLKPRNTKEVCKYNDSVNS 134

  Fly   283 ---FNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTR 344
               |:..:.|..:....|:|..:..|     :|.|..| |.|...:.:||..|::|....|..|:
Mouse   135 VSLFSTISLNQGIHMQKKKHKRNAEF-----EKVFVSK-HKDMVKQKNTGVNPYKCSEFHKYLTQ 193

  Fly   345 KEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMR 409
            :|.:....|.:.|:.|::.....|.||.:.|..:|...|||:.||:|..|.|.:|.|.:|..|.|
Mouse   194 REKLQTQQRIYHGKKPYKSSKSDKCFTHQIHLRSHQGIHTGEKPHKCSECDKCFTHKFNLRAHQR 258

  Fly   410 SHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHR 474
            .||.|..::|..|.|.|:.|.....|...||||.||:|..|.|.||.|.:|..|...||||.||:
Mouse   259 IHTGEKLYKCSECDKCFTHKSRLNYHQRIHTGEKPHKCSECDKCFTHKFNLRAHQIIHTGEKPHK 323

  Fly   475 CSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFT 539
            ||.|.|.||.|.:|..|.|.||||.|:||:.|.|.||||.|:..|.|.||||.|:||:.|.|.||
Mouse   324 CSECDKCFTHKFNLRAHQRIHTGEKPYKCSECDKCFTRKFHLGIHHRIHTGEKPYKCSECDKCFT 388

  Fly   540 RKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHM 604
            .|..|..|.|.|.|:.|::||.|.|.||.|..|..|.|:|||:.||||..|.|.||.|..|..|.
Mouse   389 GKGSLRIHQRIHIGEKPYKCSECDKCFTGKGSLRIHQRIHTGERPHKCSECDKCFTGKGSLRIHQ 453

  Fly   605 RQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQE 669
            |.|:.:.|:.|:.|:|.||:|.||..|.. .|||::|:.|.
Mouse   454 RMHTGEKPYKCSECDKCFTQKSHLNIHQG-IHTGEKPYKCS------------------------ 493

  Fly   670 MERPFACEKCPKNFICKGHLVSHMRSHSGEKPH 702
                 .|:||   |..|.||::|.:.|:||||:
Mouse   494 -----ECDKC---FTHKSHLINHQKIHTGEKPY 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/7 (57%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		C2H2 Zn finger	279..299	CDD:275368	5/30 (17%)
		COG5048	300..723	CDD:227381	161/403 (40%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		C2H2 Zn finger	503..523	CDD:275368	10/19 (53%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	1/19 (5%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368
Zfp985	NP_001014419.2	KRAB	12..52	CDD:396083
		C2H2 Zn finger	184..204	CDD:275368	5/19 (26%)
		COG5048	207..>519	CDD:227381	146/345 (42%)
		C2H2 Zn finger	216..232	CDD:275368	5/15 (33%)
		C2H2 Zn finger	240..260	CDD:275368	8/19 (42%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		C2H2 Zn finger	324..344	CDD:275368	10/19 (53%)
		C2H2 Zn finger	352..372	CDD:275368	10/19 (53%)
		C2H2 Zn finger	380..400	CDD:275368	9/19 (47%)
		C2H2 Zn finger	408..428	CDD:275368	10/19 (53%)
		C2H2 Zn finger	436..456	CDD:275368	9/19 (47%)
		C2H2 Zn finger	464..484	CDD:275368	9/20 (45%)
		C2H2 Zn finger	492..512	CDD:275368	9/51 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950