DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp992

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001078991.1	Gene:	Zfp992 / 433791	MGIID:	3700963	Length:	573	Species:	Mus musculus

Alignment Length:	521	Identity:	195/521 - (37%)
Similarity:	265/521 - (50%)	Gaps:	51/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 NVAL-APDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGK 269
            ||.| ||..||..| .|..|    ..||..|..:..|...|       ||....:.:.
Mouse    91 NVILEAPQCTPYKT-NHTSD----ALQFSNQKRLKPRNTKE-------VCKYNDSVNS------- 136

  Fly   270 IHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFR 334
                      :..|:..:.|..:....|:|:.:..     .:|.|..| |.....|::||..|::
Mouse   137 ----------LTLFSTISLNQGIHMQKKKHNGNAE-----SEKAFISK-HKVMVKRNNTGVNPYK 185

  Fly   335 CQYCAKTFTRKEHM-----VNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVC 394
            |....|..|:::.:     :.|.:||     .|.....|.||.:.....|...|..:..::|..|
Mouse   186 CSKFDKYLTQRDKLQSQQRIYHEKKH-----FRSSKSDKCFTHQIDLSIHQGIHAEEKIYKCSEC 245

  Fly   395 GKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEH 459
            .|.:|.|.||..|.|.||.|.|::|..|.|.|::|.|...|...||||.|::|..|.|.||.|.:
Mouse   246 DKCFTHKFHLNIHQRIHTGEKPYKCSECDKCFTQKSHLNIHQRIHTGEKPYKCIVCEKCFTEKGN 310

  Fly   460 LLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHT 524
            |..|.|.|||:.|::||.|.|.||:|.||..|.|.||||.|:||:.|.|:||...|:..|.|.||
Mouse   311 LRIHQRIHTGDKPYKCSECDKCFTQKSHLNIHQRIHTGEKPYKCSKCDKSFTENGHLRIHQRNHT 375

  Fly   525 GESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEY 589
            ||.|:||:.|.|:||...||..|.|.|||:.|::||.|.|.||:|..|..|.|:|.|:.|:||..
Mouse   376 GEKPYKCSQCDKSFTENGHLRIHQRIHTGEKPYKCSECDKCFTKKFSLRIHQRIHRGEKPYKCSE 440

  Fly   590 CQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLK 654
            |.|.||.|..|..|.|.|:.:.|:.|:.|:|.||....|..| .|.|||::|:.|..|.|.|..|
Mouse   441 CDKCFTFKGSLRIHQRIHTGEKPYKCSECDKSFTENGCLRIH-QRIHTGEKPYKCTECDKCFTFK 504

  Fly   655 GNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKR 719
            |:|..|||.||.    |:|:.|.:|.|:|..||.|..|.|.|:||||:.|:.|.|.|.|:|:.:.
Mouse   505 GSLRIHQRIHTG----EKPYKCTECDKSFTEKGKLRIHQRIHTGEKPYKCSECDKCFTEKGHQRI 565

  Fly   720 H 720
            |
Mouse   566 H 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	174/426 (41%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	4/24 (17%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	11/19 (58%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	9/19 (47%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Zfp992	NP_001078991.1	KRAB	13..>55	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	186..206	CDD:275368	3/19 (16%)
		C2H2 Zn finger	218..234	CDD:275368	4/15 (27%)
		C2H2 Zn finger	242..262	CDD:275368	9/19 (47%)
		zf-H2C2_2	254..279	CDD:290200	12/24 (50%)
		COG5048	266..>550	CDD:227381	135/288 (47%)
		C2H2 Zn finger	270..290	CDD:275368	7/19 (37%)
		zf-H2C2_2	282..306	CDD:290200	10/23 (43%)
		C2H2 Zn finger	298..318	CDD:275368	9/19 (47%)
		zf-H2C2_2	310..335	CDD:290200	12/24 (50%)
		C2H2 Zn finger	326..346	CDD:275368	11/19 (58%)
		zf-H2C2_2	338..362	CDD:290200	13/23 (57%)
		C2H2 Zn finger	354..374	CDD:275368	8/19 (42%)
		zf-H2C2_2	366..390	CDD:290200	12/23 (52%)
		C2H2 Zn finger	382..402	CDD:275368	9/19 (47%)
		zf-H2C2_2	394..418	CDD:290200	12/23 (52%)
		C2H2 Zn finger	410..430	CDD:275368	10/19 (53%)
		zf-H2C2_2	422..446	CDD:290200	10/23 (43%)
		C2H2 Zn finger	438..458	CDD:275368	9/19 (47%)
		zf-H2C2_2	450..474	CDD:290200	8/23 (35%)
		C2H2 Zn finger	466..486	CDD:275368	8/20 (40%)
		zf-H2C2_2	479..502	CDD:290200	10/23 (43%)
		C2H2 Zn finger	494..514	CDD:275368	10/19 (53%)
		zf-H2C2_2	506..530	CDD:290200	11/27 (41%)
		C2H2 Zn finger	522..542	CDD:275368	9/19 (47%)
		zf-H2C2_2	535..558	CDD:290200	11/22 (50%)
		C2H2 Zn finger	550..566	CDD:275368	6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950