DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp873

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_036011778.1	Gene:	Zfp873 / 408062	MGIID:	3040689	Length:	673	Species:	Mus musculus

Alignment Length:	593	Identity:	202/593 - (34%)
Similarity:	286/593 - (48%)	Gaps:	42/593 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |:...|.|...:.|..|.:.|...:|:.|..||:.: .|.....|.:.|:|...:.|..|...|.
Mouse   107 CNQYSKAFVNFHSLPQHAKNHPREQPYECNHCGKAY-VSPSSQIHKRSHVGEKPYECSKCGKAFE 170

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            |:..|:...|.|:.:|.|.|:.|.|.||.:.:|..|.|.||||.|:.|..|.|.||.:.::..|.
Mouse   171 NDNHLQNREKHHTLEKLFECSQCGKAFASRSYLPIHRRIHTGEKPYECTQCGKAFTSRSYLKIHK 235

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            ..||||.|:.|:.|.|:|........|..:||.:.|::|..|.|.:.....|..|.|:||.|.|:
Mouse   236 SVHTGEKPYECNQCSKAFANFYSLRQHEKYHTREKPYECSHCSKAFPSPSSLQVHERTHTGEKPY 300

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            .|..|||:|........|...||||.|:.|..|.|.|..:.:|..|.|.||||.|:.||.|.|.|
Mouse   301 DCTECGKAFISHSSLQIHKRVHTGEKPYECTLCGKAFVNRSYLEVHKRIHTGEKPYECSQCSKAF 365

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            .....|..|.:.||.|.|::|:.|:|||....|:..|.|.||||.|:.|:.|.|.|||..:|..|
Mouse   366 ANFRSLRQHEKNHTREKPYECSQCSKAFVSPCHLQIHQRTHTGEKPYDCSDCGKAFTRLSNLQVH 430

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            .|.|||..|:.||.|.|.|....:|..|.|.|||:.|:.|..|.|.|..:..|..|.:.|:.:.|
Mouse   431 KRTHTGQKPYCCSQCGKAFPCFSNLQIHERTHTGEKPYACNQCGKAFASRASLQYHEKHHTGEKP 495

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            :.||.|.|.|....||..| .|.|||::|:.|..|||:|..:.||..|:||||.    |:|:.|.
Mouse   496 YGCNQCGKAFVSPSHLQIH-QRTHTGEKPYECSQCGKAFARRSNLQIHERSHTG----EKPYDCN 555

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPHPQIP 742
            :|.|.|..:..|..|.:.|:||||:.|:.|.|.|..|..|:.|.:.:..:.
Mouse   556 QCGKAFASRASLQYHEKHHTGEKPYGCSQCGKGFALRSLLQVHERTHTGEK-------------- 606

  Fly   743 AGVLTQVKQEVKPIIIPHHSATTTMHTIQQITAGAAGGAG-AVQLTPGLVPLVTS-----TLISH 801
                            ||.......|..:.:.....||:| |.:...|..|:::.     :.:|.
Mouse   607 ----------------PHQCTQCGHHPPEVVEKKGYGGSGPAKKWFFGASPVLSGNWQFISQVSI 655

  Fly   802 NAAAQQQS 809
            |::...|:
Mouse   656 NSSVYSQT 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	169/422 (40%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Zfp873	XP_036011778.1	KRAB	4..44	CDD:396083
		C2H2 Zn finger	107..127	CDD:275368	5/19 (26%)
		C2H2 Zn finger	135..154	CDD:275368	5/19 (26%)
		COG5048	158..573	CDD:227381	164/419 (39%)
		C2H2 Zn finger	162..182	CDD:275368	6/19 (32%)
		C2H2 Zn finger	190..210	CDD:275368	8/19 (42%)
		C2H2 Zn finger	218..238	CDD:275368	6/19 (32%)
		C2H2 Zn finger	246..266	CDD:275368	5/19 (26%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		C2H2 Zn finger	470..490	CDD:275368	6/19 (32%)
		C2H2 Zn finger	498..518	CDD:275368	9/20 (45%)
		C2H2 Zn finger	526..546	CDD:275368	9/19 (47%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950