DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF880

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001138906.1	Gene:	ZNF880 / 400713	HGNCID:	37249	Length:	577	Species:	Homo sapiens

Alignment Length:	428	Identity:	176/428 - (41%)
Similarity:	230/428 - (53%)	Gaps:	33/428 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 KPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQ 311
            ||..|...|:.|..|..|                      |||..:      |:.|.|:.|..|.
Human   182 KPCECNEHGKAFRVSSRL----------------------ANNQVI------HTADNPYKCNECD 218

  Fly   312 KTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHY 376
            |.|:...:|..|.|.||||.|::|..|.|.|.|...:..|.|.||||.|::|..|.|.||:..|.
Human   219 KVFSNSSNLVQHQRIHTGEKPYKCHECGKLFNRISLLARHQRIHTGEKPYKCHECGKVFTQNSHL 283

  Fly   377 VNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTG 441
            .||:..|||:.|::|:.|||.:.|..|||.|.:.|:.|.|::|:.|||:||.....|.|::.|||
Human   284 ANHHRIHTGEKPYKCNECGKVFNRNAHLARHQKIHSGEKPYKCKECGKAFSGGSGLTAHLVIHTG 348

  Fly   442 ETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYC 506
            |..::|:.|.|.|.|..||..|.|.||||.|:.|..|.|.|..|..|.||.|.||||.|:||..|
Human   349 EKLYKCNKCGKVFNRNAHLTRHQRIHTGEKPYECKECGKVFRHKFCLTNHHRMHTGEQPYKCNEC 413

  Fly   507 TKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEH 571
            .|||.....:..|:..||||.|:||..|.|.|..:..|:||.|.|||:.|:||..|.|.|||..:
Human   414 GKAFRDCSGLTAHLLIHTGEKPYKCKECAKVFRHRLSLSNHQRFHTGEKPYRCDECGKDFTRNSN 478

  Fly   572 LTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCH 636
            |.||.|:|||:.|:||..|.|.|:...||..|.:.|:.:..:.||.|.|.|:.|.:|..| .|.|
Human   479 LANHHRIHTGEKPYKCSECHKVFSHNSHLARHRQIHTGEKSYKCNECGKVFSHKLYLKKH-ERIH 542

  Fly   637 TGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPF 674
            ||::|:.|..|||.|....||..|.|.||.    |:|:
Human   543 TGEKPYRCHECGKDFTRNSNLANHHRIHTG----EKPY 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	165/375 (44%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF880	NP_001138906.1	KRAB	7..65	CDD:214630
		KRAB	7..46	CDD:279668
		COG5048	162..568	CDD:227381	171/414 (41%)
		C2H2 Zn finger	186..206	CDD:275368	8/47 (17%)
		zf-C2H2	212..234	CDD:278523	7/21 (33%)
		C2H2 Zn finger	214..234	CDD:275368	7/19 (37%)
		zf-H2C2_2	226..251	CDD:290200	12/24 (50%)
		C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		zf-H2C2_2	255..279	CDD:290200	11/23 (48%)
		C2H2 Zn finger	270..290	CDD:275368	8/19 (42%)
		zf-H2C2_2	282..307	CDD:290200	11/24 (46%)
		C2H2 Zn finger	298..318	CDD:275368	9/19 (47%)
		zf-H2C2_2	310..334	CDD:290200	11/23 (48%)
		C2H2 Zn finger	326..346	CDD:275368	8/19 (42%)
		zf-C2H2	352..374	CDD:278523	9/21 (43%)
		C2H2 Zn finger	354..374	CDD:275368	9/19 (47%)
		zf-H2C2_2	366..391	CDD:290200	13/24 (54%)
		C2H2 Zn finger	382..402	CDD:275368	9/19 (47%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368	8/19 (42%)
		zf-H2C2_2	450..475	CDD:290200	13/24 (54%)
		C2H2 Zn finger	466..486	CDD:275368	10/19 (53%)
		zf-H2C2_2	478..503	CDD:290200	13/24 (54%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		zf-H2C2_2	506..531	CDD:290200	9/24 (38%)
		C2H2 Zn finger	522..542	CDD:275368	9/20 (45%)
		zf-H2C2_2	534..559	CDD:290200	12/25 (48%)
		C2H2 Zn finger	550..570	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900