DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF790

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001229729.1	Gene:	ZNF790 / 388536	HGNCID:	33114	Length:	636	Species:	Homo sapiens

Alignment Length:	506	Identity:	167/506 - (33%)
Similarity:	229/506 - (45%)	Gaps:	48/506 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 CGKMFQFRYQLI--VHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFAN 288
            |.|...|....:  :|:|.::..|....:..|:.|.:..|.|:|..||..........|.|.|..
Human   145 CEKRPTFNQHTVFNLHQRLNTGDKLNEFKELGKAFISGSDHTQHQLIHTSEKFCGDKECGNTFLP 209

  Fly   289 NTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVR 353
            ::.:.::...|:..|.:.|..|.|:|:.:..|..|.|.||||.||:|:.|.|.|.....:..|.|
Human   210 DSEVIQYQTVHTVKKTYECKECGKSFSLRSSLTGHKRIHTGEKPFKCKDCGKAFRFHSQLSVHKR 274

  Fly   354 KHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFR 418
            .||||..:.|..|.|:|:                      ||...||      |.|.||.|.|:.
Human   275 IHTGEKSYECKECGKAFS----------------------CGSDLTR------HQRIHTGEKPYE 311

  Fly   419 CEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFT 483
            |..|.|:||::.|...|...||||.|:.|..|.|.|||..||..|.|.||||..|.|..|.|.|.
Human   312 CNECRKAFSQRSHLIKHQRIHTGEKPYECKECGKAFTRGSHLTQHQRIHTGEKSHECKECGKAFI 376

  Fly   484 RKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHV 548
            |..:|..|...|.|..|:||..|.||:....|:..|.|.|||..|::|..|.||||...:|..|.
Human   377 RGSNLAQHQNVHVGRKPYKCEKCGKAYIWSSHLARHQRIHTGRKPYECKQCGKTFTWASYLAQHE 441

  Fly   549 RQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPH 613
            :.|.....:.|..|.|||........|.::|||:..::|:.|.|||.|...||.|.:.|:...|:
Human   442 KIHNERKSYECKECGKTFLHGSEFNRHQKIHTGERNYECKECGKTFFRGSELNRHQKIHTGKRPY 506

  Fly   614 CCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEK 678
            .|..|.|.|.....|..| .|.|||:.|:.|:.|||||.....|..|::.||..:    |:.|:|
Human   507 ECEECGKAFLWGSQLTRH-QRMHTGEEPYVCKECGKSFIWGSQLTRHKKIHTDAE----PYGCKK 566

  Fly   679 CPKNFICKGHLVSHMRSHSGEKPH-ACTLC-----SKAFVERGNLKRHMKM 723
                   ..|:.||....:.:|.| :..||     ...|....|..:|..:
Human   567 -------SSHIFSHHSYFTEQKIHNSANLCEWTDYGNTFSHESNFAQHQNI 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/18 (28%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	150/428 (35%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	10/19 (53%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..722	CDD:275368	5/22 (23%)
ZNF790	NP_001229729.1	KRAB	5..64	CDD:214630
		KRAB	5..44	CDD:279668
		C2H2 Zn finger	145..164	CDD:275368	5/18 (28%)
		C2H2 Zn finger	172..192	CDD:275368	5/19 (26%)
		COG5048	<183..361	CDD:227381	69/205 (34%)
		C2H2 Zn finger	201..220	CDD:275368	3/18 (17%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		zf-H2C2_2	240..263	CDD:290200	12/22 (55%)
		C2H2 Zn finger	256..276	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..293	CDD:290200	10/45 (22%)
		C2H2 Zn finger	284..304	CDD:275368	10/47 (21%)
		zf-H2C2_2	296..321	CDD:290200	12/30 (40%)
		COG5048	308..>575	CDD:227381	106/278 (38%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		zf-H2C2_2	324..349	CDD:290200	11/24 (46%)
		C2H2 Zn finger	340..360	CDD:275368	10/19 (53%)
		zf-H2C2_2	352..377	CDD:290200	13/24 (54%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		C2H2 Zn finger	396..416	CDD:275368	7/19 (37%)
		zf-H2C2_2	408..432	CDD:290200	11/23 (48%)
		C2H2 Zn finger	424..444	CDD:275368	8/19 (42%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..487	CDD:290200	7/22 (32%)
		C2H2 Zn finger	480..500	CDD:275368	9/19 (47%)
		zf-H2C2_2	492..515	CDD:290200	8/22 (36%)
		C2H2 Zn finger	508..528	CDD:275368	7/20 (35%)
		zf-H2C2_2	521..543	CDD:290200	11/22 (50%)
		C2H2 Zn finger	536..556	CDD:275368	8/19 (42%)
		C2H2 Zn finger	564..583	CDD:275368	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810