DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZKSCAN4

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_061983.2	Gene:	ZKSCAN4 / 387032	HGNCID:	13854	Length:	545	Species:	Homo sapiens

Alignment Length:	279	Identity:	102/279 - (36%)
Similarity:	139/279 - (49%)	Gaps:	25/279 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 KKYTRKEH-LANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEH 459
            ||...||| ...|:|....:.|...| .|:...|.:....:.:   |...|.|..|.|:|.:...
Human   274 KKLPEKEHGKICHLREDIAQIPTHAE-AGEQEGRLQRKQKNAI---GSRRHYCHECGKSFAQSSG 334

  Fly   460 LLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHT 524
            |..|.|.||||.|:.|..|.|||.....||.|.|.||||.|::|..|.|.|:...:::.|.|.||
Human   335 LTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHT 399

  Fly   525 GESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEY 589
            ||.|::|..|.|||::...|..|.:.|||:.|::|:.|.|.|.|..||..|.|:| ||
Human   400 GEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIH-GD------- 456

  Fly   590 CQKTFTRKEHLNNHMRQHSSDN---------PHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCE 645
              |.....||..:...|..:::         .:.||.|.:.|||...||.| .:.|||::|:.|:
Human   457 --KNVQNPEHGESWESQGRTESQWENTEAPVSYKCNECERSFTRNRSLIEH-QKIHTGEKPYQCD 518

  Fly   646 TCGKSFPLKGNLLFHQRSH 664
            ||||.|.....|:.|||||
Human   519 TCGKGFTRTSYLVQHQRSH 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	102/279 (37%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368
		C2H2 Zn finger	363..383	CDD:275368
		C2H2 Zn finger	391..411	CDD:275368	7/15 (47%)
		C2H2 Zn finger	419..439	CDD:275368	3/19 (16%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	3/19 (16%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZKSCAN4	NP_061983.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..55
		SCAN	49..160	CDD:128708
		KRAB	221..281	CDD:214630	3/6 (50%)
		zf-C2H2	320..342	CDD:306579	8/21 (38%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..357	CDD:316026	11/21 (52%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		COG5048	<374..544	CDD:227381	64/175 (37%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..480		6/33 (18%)
		C2H2 Zn finger	489..509	CDD:275368	9/20 (45%)
		C2H2 Zn finger	517..537	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010