DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and Zfp229

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001158148.1	Gene:	Zfp229 / 381067	MGIID:	2679295	Length:	705	Species:	Mus musculus

Alignment Length:	499	Identity:	184/499 - (36%)
Similarity:	257/499 - (51%)	Gaps:	9/499 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 CGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNT 290
            |.|.|. .:..:|..|.||.:.|..|:.|..||.|...|:.|.:.:.|...:.|..|...|...:
Mouse   207 CDKTFG-SFPKLVQLRIHSGKNPQKCRKCRTGFRTCSSLSTHQRTYTGEKPWICTECDKAFRWLS 270

  Fly   291 SLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKH 355
            .|:.|.:.|..:|||.|..|.::|.....|..|...|.|:. ::|..|.|.|||...:..|.:.|
Mouse   271 DLKTHYRIHPGEKPFKCKECDRSFTFYNSLREHQNIHKGKL-YKCWKCDKFFTRCSSLRAHEKIH 334

  Fly   356 TGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCE 420
            |||.|.:|..|.|||........|...|||:.|::|..|.|.:|....|..|...|..:. ::|:
Mouse   335 TGEKPFKCKECIKSFYMLSQLRKHARTHTGEKPYKCKECDKSFTYSSSLREHQNMHAGKL-YKCQ 398

  Fly   421 ICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRK 485
            .|.|.|:.......|...||||.|.:|..|.|:|.....|..|.|.||||.|::|..|.|:||:.
Mouse   399 ECDKCFTWCSSLRAHEKIHTGEKPFKCKECGKSFCMLSQLRKHARTHTGEKPYKCKECEKSFTQC 463

  Fly   486 EHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQ 550
            ..|..|.:.|.||.|:||..|.|.|.:..::..|.|.||||.|::|..|.|.|::...|.:|.|.
Mouse   464 STLRIHQKIHAGEKPYKCKECGKCFYKLSYLKVHYRTHTGEKPYQCKECGKGFSQLSCLKSHERI 528

  Fly   551 HTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCC 615
            |||:.|::||.|.|:||.......|...|.. .|:|||.|.|:|.::..|..|.:.|:.:.||.|
Mouse   529 HTGEKPYKCSECDKSFTHCSTCRRHQSTHAA-KPYKCEECDKSFAKQSSLRTHQKVHAGEKPHAC 592

  Fly   616 NVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCP 680
            ..|.|.|.:..||..|. |.|||::|:.|:.|.|||....:|..||:.|..    |:|.|||||.
Mouse   593 KECGKAFYQLSHLKVHY-RIHTGEKPYKCDECEKSFTKCSSLRTHQKIHAG----EKPHACEKCG 652

  Fly   681 KNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            |.|....||..|.|:|:||||:.|:.|.|:|....||:||.:::
Mouse   653 KAFYHLSHLNIHYRTHTGEKPYKCSDCDKSFTTLANLRRHHRLH 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/16 (31%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	162/422 (38%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	10/19 (53%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
Zfp229	NP_001158148.1	KRAB	13..73	CDD:214630
		C2H2 Zn finger	205..223	CDD:275368	5/16 (31%)
		COG5048	<227..412	CDD:227381	58/186 (31%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		C2H2 Zn finger	259..279	CDD:275368	5/19 (26%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		COG5048	338..704	CDD:227381	141/366 (39%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		C2H2 Zn finger	592..612	CDD:275368	8/20 (40%)
		C2H2 Zn finger	620..640	CDD:275368	8/19 (42%)
		C2H2 Zn finger	648..668	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950