DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF568

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	461	Identity:	185/461 - (40%)
Similarity:	269/461 - (58%)	Gaps:	19/461 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRR---------------YHSER---KPFMCQVCGQGFTTSQDLTRHGK 269
            ||...|..:....|:.:.:               ||...   .||.|..|||.|:...||.||.:
Human   178 CDSLDKGLEHNLDLLRYEKGCVREKQSNEFGKPFYHCASYVVTPFKCNQCGQDFSHKFDLIRHER 242

  Fly   270 IHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFR 334
            ||.|...:.|..|...|:...:|..|.|.|:.:||:.|..|.|.|.:..:|..|.|.||||.|:.
Human   243 IHAGEKPYECKECGKAFSRKENLITHQKIHTGEKPYKCNECGKAFIQMSNLIRHHRIHTGEKPYA 307

  Fly   335 CQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYT 399
            |:.|.|.|::|.:::.|.|.||||.|:.|..|.|||::|::.:.|...|||:.|:.|:.||:.::
Human   308 CKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKSFSQKQNLIEHEKIHTGEKPYACNECGRAFS 372

  Fly   400 RKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHV 464
            |...:..||||||.|.|::|..|||:||:...|..|:..||||.|:.|..|.|.|::...|..|:
Human   373 RMSSVTLHMRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSLTVHM 437

  Fly   465 RQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPH 529
            |.||.|.|:.|..|.|.|:|||:|:.|.:.||||.|::|:.|.|||.:..:::.|.|.||||.|:
Human   438 RNHTAEKPYECKECGKAFSRKENLITHQKIHTGEKPYECSECGKAFIQMSNLIRHQRIHTGEKPY 502

  Fly   530 KCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTF 594
            .||.|.|.|::|.:||.|.:.|||:.|:.|:.|.|.|:::::|..|.::|||:.|.||..|.|.|
Human   503 ACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHTGEKPFKCNECGKAF 567

  Fly   595 TRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLF 659
            :|...|..|:|.|:.:.|:.||.|.|.|::...||.|| |.|||::||.|..|||:|..:.:|..
Human   568 SRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLIIHM-RSHTGEKPFECNECGKAFSQRASLSI 631

  Fly   660 HQRSHT 665
            |:|.||
Human   632 HKRGHT 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/34 (12%)
		C2H2 Zn finger	251..271	CDD:275368	9/19 (47%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	158/366 (43%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368	9/19 (47%)
		zf-H2C2_2	236..261	CDD:290200	10/24 (42%)
		COG5048	248..634	CDD:227381	162/386 (42%)
		C2H2 Zn finger	252..272	CDD:275368	6/19 (32%)
		zf-H2C2_2	264..289	CDD:290200	10/24 (42%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		zf-H2C2_2	292..317	CDD:290200	12/24 (50%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		zf-H2C2_2	320..345	CDD:290200	12/24 (50%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		zf-H2C2_2	348..373	CDD:290200	8/24 (33%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		zf-H2C2_2	380..401	CDD:290200	13/20 (65%)
		C2H2 Zn finger	392..412	CDD:275368	8/19 (42%)
		zf-H2C2_2	408..429	CDD:290200	10/20 (50%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..457	CDD:290200	11/24 (46%)
		C2H2 Zn finger	448..468	CDD:275368	9/19 (47%)
		zf-H2C2_2	460..485	CDD:290200	12/24 (50%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:290200	12/24 (50%)
		C2H2 Zn finger	504..524	CDD:275368	9/19 (47%)
		zf-H2C2_2	516..541	CDD:290200	11/24 (46%)
		C2H2 Zn finger	532..552	CDD:275368	6/19 (32%)
		zf-H2C2_2	544..569	CDD:290200	11/24 (46%)
		C2H2 Zn finger	560..580	CDD:275368	8/19 (42%)
		zf-H2C2_2	572..597	CDD:290200	10/24 (42%)
		C2H2 Zn finger	588..608	CDD:275368	10/20 (50%)
		zf-H2C2_2	601..625	CDD:290200	15/24 (63%)
		C2H2 Zn finger	616..636	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860