DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF699

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_940937.1	Gene:	ZNF699 / 374879	HGNCID:	24750	Length:	642	Species:	Homo sapiens

Alignment Length:	503	Identity:	177/503 - (35%)
Similarity:	255/503 - (50%)	Gaps:	37/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 NGGGQNVALAPDGTPIATGTHV----CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTS 261
            |..||..:..|:...:...|.|    |..|||.|.....|..|.|.|:..||:.|:.||:.|
Human   171 NQDGQTFSQVPNLDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAF--- 232

  Fly   262 QDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRS 326
                     |.       :.||         ::|||..:.:||:.|..|.|.|:.......|.:.
Human   233 ---------HF-------LACF---------KKHMKTPTEEKPYECKECTKAFSCSSFFRAHMKI 272

  Fly   327 HTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQC 391
            |.|:|.:.|:.|.|.|:....:..|.|.|:|:.|:.|..|.|:|:.......|...|:|..|::|
Human   273 HIGKTNYECKECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHKRIHSGDKPYEC 337

  Fly   392 DVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTR 456
            ..|||.::...||..|:|.||.|.|:.|:.|||:||.....|.|...||||.|::|..|.|.:..
Human   338 KECGKAFSSSSHLIIHIRIHTGEKPYECKECGKAFSESSKLTVHGRTHTGEKPYKCKECGKAYNC 402

  Fly   457 KEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVR 521
            ...|..|:|:||||.|:.|..|.|.|.....|..|::..:.|.|::|..|.|||:.......|||
Human   403 PSSLSIHMRKHTGEKPYECLECGKAFYLPTSLNTHVKNQSREKPYECKECGKAFSCPSSFRAHVR 467

  Fly   522 QHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHK 586
            .|||:..::|..|.|||:|...||.|:|.|:|:.|:.|..|.|.|....|||.|:|.|||:.|::
Human   468 DHTGKIQYECKECGKTFSRSSSLTEHLRTHSGEKPYECKECGKAFISSSHLTVHIRTHTGEKPYE 532

  Fly   587 CEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSF 651
            |:.|.|.|.....|..|||.|:.:.|:.|..|.|.|....:|..| :|.|||::||.|..|||:|
Human   533 CKKCGKAFIYPSALRIHMRTHTGEKPYECKECGKAFRHSSYLTVH-ARMHTGEKPFECLECGKAF 596

  Fly   652 PLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGE 699
            ....:...|.||||.    |:|:.|::|.|.|:|..:...|:::|:.|
Human   597 SCPSSFRRHVRSHTG----EKPYECKECGKAFVCPAYFRRHVKTHTRE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	150/400 (38%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	10/19 (53%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF699	NP_940937.1	KRAB	19..79	CDD:214630
		KRAB	19..58	CDD:279668
		C2H2 Zn finger	143..159	CDD:275368
		C2H2 Zn finger	167..189	CDD:275368	4/17 (24%)
		COG5048	171..605	CDD:227381	162/462 (35%)
		C2H2 Zn finger	197..217	CDD:275368	8/19 (42%)
		zf-H2C2_2	209..233	CDD:290200	10/35 (29%)
		C2H2 Zn finger	225..245	CDD:275368	10/47 (21%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	293..318	CDD:290200	9/24 (38%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		zf-H2C2_2	321..346	CDD:290200	8/24 (33%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	349..373	CDD:290200	12/23 (52%)
		C2H2 Zn finger	365..385	CDD:275368	8/19 (42%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		zf-H2C2_2	405..428	CDD:290200	11/22 (50%)
		C2H2 Zn finger	421..439	CDD:275368	6/17 (35%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		zf-C2H2	475..497	CDD:278523	10/21 (48%)
		C2H2 Zn finger	477..497	CDD:275368	10/19 (53%)
		zf-H2C2_2	489..514	CDD:290200	11/24 (46%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		zf-H2C2_2	517..542	CDD:290200	13/24 (54%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
		zf-H2C2_2	545..570	CDD:290200	10/24 (42%)
		C2H2 Zn finger	561..581	CDD:275368	7/20 (35%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		zf-H2C2_2	601..626	CDD:290200	11/28 (39%)
		C2H2 Zn finger	617..637	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960