DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and ZNF233

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_024307256.1	Gene:	ZNF233 / 353355	HGNCID:	30946	Length:	727	Species:	Homo sapiens

Alignment Length:	463	Identity:	156/463 - (33%)
Similarity:	230/463 - (49%)	Gaps:	31/463 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 GIHGVDGSGNGGNGGGQNVALAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQV 253
            |:|..:.:.:..|.|...|..:...:.|.:|....|..||.......|.:|::.|...||.:...
Human   283 GVHKREKAFSHNNCGKDCVKESSQHSIIQSGEQTSDENGKGLSVGSNLELHQQLHLRDKPHVNVE 347

  Fly   254 CGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKE 318
            .|:|...|..|.||...|||..      |:.   |..|.|                   .|::..
Human   348 YGKGIGYSSGLPRHQCFHIGEK------CYR---NGDSGE-------------------GFSQGS 384

  Fly   319 HLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWH 383
            ||..|.|..|||..:|||..|::..:...:.:|...|.||....|..|.|.|.....:..|.:..
Human   385 HLQPHQRVSTGENLYRCQVYARSSNQNSCLPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDS 449

  Fly   384 TGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCD 448
            .|:...:|||..|.:::...|..|.|.|:.:..::.|:..:.|:|.......:  ||||.|::|:
Human   450 AGERACKCDVYDKGFSQTSQLQAHQRGHSRDKTYKWEVSDRIFNRNSGLHQRV--HTGEKPYKCE 512

  Fly   449 FCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRK 513
            .|.|.|::..:|..|.|.||||.|::|..|.|.|:|..||..|.|.||||.|:||..|.|.|::.
Human   513 VCDKGFSKASNLQAHQRIHTGEKPYKCDVCDKNFSRNSHLQAHQRVHTGEKPYKCDTCGKDFSQI 577

  Fly   514 DHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRL 578
            .|:..|.|.|.||.|:||..|.|.|::..||.:|.:.|||::|::|..|.|.|:...||..|.|:
Human   578 SHLQAHQRVHKGEKPYKCETCGKGFSQSSHLQDHQQVHTGENPYKCDVCGKGFSWSSHLQAHQRV 642

  Fly   579 HTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFT 643
            |||:.|:|||.|:|.|....:|:.|.|.|:.:.|:.|.:|.|.|::..||..| .|.|||::|:.
Human   643 HTGEKPYKCEECRKGFIWNSYLHVHQRIHTGEKPYKCGMCGKSFSQTSHLQAH-QRVHTGEKPYK 706

  Fly   644 CETCGKSF 651
            |..|||.|
Human   707 CFVCGKGF 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	4/19 (21%)
		COG5048	300..723	CDD:227381	128/352 (36%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	3/19 (16%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	5/8 (63%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF233	XP_024307256.1	KRAB	65..123	CDD:214630
		C2H2 Zn finger	321..337	CDD:275368	4/15 (27%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	377..393	CDD:275368	6/34 (18%)
		C2H2 Zn finger	401..421	CDD:275368	4/19 (21%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		COG5048	<507..656	CDD:227381	67/148 (45%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	9/19 (47%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	8/19 (42%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		zf-C2H2	677..699	CDD:306579	8/22 (36%)
		C2H2 Zn finger	679..699	CDD:275368	8/20 (40%)
		zf-H2C2_2	691..714	CDD:316026	12/23 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900