DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF429

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_016882237.1	Gene:	ZNF429 / 353088	HGNCID:	20817	Length:	689	Species:	Homo sapiens

Alignment Length:	529	Identity:	197/529 - (37%)
Similarity:	283/529 - (53%)	Gaps:	17/529 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 GGNGGGQNVALAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRY---HSERKPFMCQVCGQGFTT 260
            |.||..|.:.|.      .:..:.|||..|:|   |......||   |:.:|||.|:.||:.|..
Human   144 GYNGLNQCLTLT------QSKMYHCDIYVKVF---YAFSNADRYKTRHTGKKPFQCKKCGKSFCM 199

  Fly   261 SQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFR 325
            ...||:|.||||....:.|....|.|..:::|..|.:.:..:|.:.|..|.|.|.....|.||.|
Human   200 LSQLTQHKKIHIRENTYRCKEFGNAFNQSSALTNHKRIYVGEKHYRCEECGKAFNHYSTLTNHKR 264

  Fly   326 SHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQ 390
            .||||.|::|:.|.|.|:|...:..|.|.|:||.|::||.|.|:|:....:..|.:.||.:.|::
Human   265 IHTGEKPYKCKECGKAFSRYSTLTTHKRIHSGEKPYKCDECGKTFSISSTFTKHKIIHTEEKPYK 329

  Fly   391 CDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFT 455
            |..|||.:.|...|.:|.|.||.|.|::||.|||:|:.....|.|.:.||||.|::|:.|.|.|.
Human   330 CKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFN 394

  Fly   456 RKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHV 520
            :...|..|.:.||||.|::...|.:.||....|....:.||||.|:.|..|.|.||....:..|.
Human   395 QSSRLTRHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIHTGEKPYNCEECGKVFTYSSTLTRHK 459

  Fly   521 RQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPH 585
            |.||.|.|:||..|.|.|.|..|||:|.|.|||:.|::|..|.|.|.:..:|.:|.::|:|:.|:
Human   460 RIHTEEKPYKCNECGKAFNRSSHLTSHRRIHTGEKPYKCEECGKAFKQSSNLNSHKKIHSGEKPY 524

  Fly   586 KCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKS 650
            |||.|.|.|.....|..|.:.|:.:.|:.|..|.|.|.|...|..| .:.|||::|:.|:.|.|:
Human   525 KCEECGKAFILSSRLTQHKKIHTGEKPYKCEECGKAFNRSSRLTQH-KKIHTGEKPYKCKQCDKA 588

  Fly   651 FPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERG 715
            |....||..|::.|:.    |:|:.||:|.|.|.....|..|.:.|:.|||:.|..|:|||....
Human   589 FTHSSNLSSHKKIHSG----EKPYKCEECGKAFNRSSRLTQHKKIHTREKPYKCEECAKAFTRSS 649

  Fly   716 NLKRHMKMN 724
            .|.:|.|::
Human   650 RLTQHKKIH 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/22 (36%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	163/422 (39%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	4/19 (21%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	10/19 (53%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF429	XP_016882237.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860