DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF81

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001365081.1	Gene:	ZNF81 / 347344	HGNCID:	13156	Length:	661	Species:	Homo sapiens

Alignment Length:	481	Identity:	168/481 - (34%)
Similarity:	239/481 - (49%)	Gaps:	5/481 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 SERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACT 308
            |:::|......|:.|..:.||..|.|.:....:...|....||..|:|...|...|:..|.....
Human   185 SQKRPHKRDSFGKSFKHNLDLHIHNKSNAAKNLDKTIGHGQVFTQNSSYSHHENTHTGVKFCERN 249

  Fly   309 ICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRK 373
            .|.|..:.|..|..:.:...||....|....|.||::.|.....:.||.|.||....|...||:|
Human   250 QCGKVLSLKHSLSQNVKFPIGEKANTCTEFGKIFTQRSHFFAPQKIHTVEKPHELSKCVNVFTQK 314

  Fly   374 EHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILW 438
            .....:...|..:..:.|..|||.:.:...|..|.::||.|.|::|..|||||.:......|...
Human   315 PLLSIYLRVHRDEKLYICTKCGKAFIQNSELIMHEKTHTREKPYKCNECGKSFFQVSSLLRHQTT 379

  Fly   439 HTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKC 503
            ||||....|..|.|.|:....|..|.:.||||..|:||.|.|.||:|..|..|.|.||||..:.|
Human   380 HTGEKLFECSECGKGFSLNSALNIHQKIHTGERHHKCSECGKAFTQKSTLRMHQRIHTGERSYIC 444

  Fly   504 TYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTR 568
            |.|.:||.:|.|::.|.|.||||.|::|:.|.|:|..|..|..|.|.|||:.|:.|:.|.|.||.
Human   445 TQCGQAFIQKAHLIAHQRIHTGEKPYECSDCGKSFPSKSQLQMHKRIHTGEKPYICTECGKAFTN 509

  Fly   569 KEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMS 633
            :.:|..|.:.|||:..:.|..|.|.||.:.:.|.|...|:.:.|:.|..|.:.|.:|..||.| .
Human   510 RSNLNTHQKSHTGEKSYICAECGKAFTDRSNFNKHQTIHTGEKPYVCADCGRAFIQKSELITH-Q 573

  Fly   634 RCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSG 698
            |.||.::|:.|..|.|||..|.:|..|||.||.    |:|:.|.:|.|.|..:.:...|...|:|
Human   574 RIHTTEKPYKCPDCEKSFSKKPHLKVHQRIHTG----EKPYICAECGKAFTDRSNFNKHQTIHTG 634

  Fly   699 EKPHACTLCSKAFVERGNLKRHMKMN 724
            :||:.|:.|.|.|.::..|..|..::
Human   635 DKPYKCSDCGKGFTQKSVLSMHRNIH 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	153/422 (36%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
ZNF81	NP_001365081.1	KRAB	21..81	CDD:214630
		C2H2 Zn finger	249..268	CDD:275368	4/18 (22%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		C2H2 Zn finger	307..324	CDD:275368	4/16 (25%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		COG5048	356..>651	CDD:227381	120/299 (40%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	416..436	CDD:275368	10/19 (53%)
		C2H2 Zn finger	444..464	CDD:275368	9/19 (47%)
		C2H2 Zn finger	472..492	CDD:275368	8/19 (42%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	528..548	CDD:275368	7/19 (37%)
		C2H2 Zn finger	556..576	CDD:275368	8/20 (40%)
		C2H2 Zn finger	584..604	CDD:275368	10/19 (53%)
		C2H2 Zn finger	612..632	CDD:275368	5/19 (26%)
		C2H2 Zn finger	640..660	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860