DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF860

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001131146.2	Gene:	ZNF860 / 344787	HGNCID:	34513	Length:	632	Species:	Homo sapiens

Alignment Length:	460	Identity:	166/460 - (36%)
Similarity:	235/460 - (51%)	Gaps:	9/460 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 GNGGGQNVALAPDGTPIATG--------THVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQ 256
            |..|.|......|.:.:.|.        .|:.:.....|.....|.:.:..|...|.|.|...|:
Human   173 GKVGNQVEKSINDASSVLTSQRISSRPKIHISNNYENNFFHSSLLTLKQEVHIREKSFQCNESGK 237

  Fly   257 GFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLD 321
            .|..|..|.:|..|::||..:.|.||..||.....|..|.:.|:.:||:.|..|.|.|.::.:|.
Human   238 AFNCSSLLRKHQIIYLGGKQYKCDVCGKVFNQKRYLACHHRCHTGEKPYKCNECGKVFNQQSNLA 302

  Fly   322 NHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQ 386
            :|.|.||||.|::|:.|.|.|:||.::..|.|.||||.|::|.:|:|:|.|..|...|...|||:
Human   303 SHHRLHTGEKPYKCEECDKVFSRKSNLERHRRIHTGEKPYKCKVCEKAFRRDSHLTQHTRIHTGE 367

  Fly   387 TPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCS 451
            .|::|:.|||.::.:..|.:|...|.....::|..|.|.||......||...|..|..::|:.|.
Human   368 KPYKCNECGKAFSGQSTLIHHQAIHGIGKLYKCNDCHKVFSNATTIANHWRIHNEERSYKCNKCG 432

  Fly   452 KTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHM 516
            |.|.|:.:|:.|.|.||||.|::|:.|.|||.....||.|...||||.|:||..|.|.|.....:
Human   433 KFFRRRSYLVVHWRTHTGEKPYKCNECGKTFHHNSALVIHKAIHTGEKPYKCNECGKTFRHNSAL 497

  Fly   517 VNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTG 581
            |.|...||||.|:||..|.|.|.::..|..|.|.|||:.|::|..|...|:||.|...|.|:|||
Human   498 VIHKAIHTGEKPYKCNECGKVFNQQATLARHHRLHTGEKPYKCEECDTVFSRKSHHETHKRIHTG 562

  Fly   582 DSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCET 646
            :.|:||:...:.|::........|.|..:..|.|:.|.|.||...|.|.| .|.|||.:.:.|..
Human   563 EKPYKCDDFDEAFSQASSYAKQRRIHMGEKHHKCDDCGKAFTSHSHRIRH-QRIHTGQKSYKCHK 626

  Fly   647 CGKSF 651
            .||.|
Human   627 RGKVF 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	2/19 (11%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		COG5048	300..723	CDD:227381	138/352 (39%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	3/19 (16%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	4/8 (50%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF860	NP_001131146.2	KRAB	24..>64	CDD:214630
		KRAB	24..63	CDD:279668
		COG5048	<179..388	CDD:227381	68/208 (33%)
		C2H2 Zn finger	232..252	CDD:275368	6/19 (32%)
		C2H2 Zn finger	260..280	CDD:275368	7/19 (37%)
		COG5048	284..617	CDD:227381	131/333 (39%)
		C2H2 Zn finger	288..308	CDD:275368	7/19 (37%)
		zf-H2C2_2	300..325	CDD:290200	12/24 (50%)
		C2H2 Zn finger	316..336	CDD:275368	8/19 (42%)
		zf-H2C2_2	328..353	CDD:290200	11/24 (46%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		zf-H2C2_2	356..380	CDD:290200	10/23 (43%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	428..448	CDD:275368	8/19 (42%)
		C2H2 Zn finger	456..476	CDD:275368	8/19 (42%)
		zf-H2C2_2	468..493	CDD:290200	13/24 (54%)
		C2H2 Zn finger	484..504	CDD:275368	6/19 (32%)
		zf-H2C2_2	496..521	CDD:290200	12/24 (50%)
		C2H2 Zn finger	512..532	CDD:275368	7/19 (37%)
		C2H2 Zn finger	540..560	CDD:275368	8/19 (42%)
		C2H2 Zn finger	596..616	CDD:275368	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900