DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF850

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	502	Identity:	200/502 - (39%)
Similarity:	267/502 - (53%)	Gaps:	5/502 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |..|||.|..|..||.|:|.|:..||:.|:.||:.||....|.:|.:||.|...:.|..|...|.
Human   563 CKECGKSFTSRSALIQHQRIHTGEKPYHCKECGKSFTVGSTLLQHQQIHTGEKPYDCKECGKAFR 627

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            ....|.:|.:.|:.:||:.|..|.|.|.....|..|.|.||||.|:.|..|.|.|.::.::..|.
Human   628 LRLRLTQHQQIHTGEKPYQCQECGKAFVSVSGLTQHHRIHTGEKPYECPDCGKAFRQRTYLNQHR 692

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            |.||||.|:.|..|.||||.....:.|...||.:.|:....|||.:|....|..|.:.||.|.|:
Human   693 RIHTGEKPYECKECGKSFTFCSGLIQHQQNHTDEKPYDGKECGKSFTSHSTLIQHQQIHTGEKPY 757

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            .|:.|||||:.......|...||||..:.|..|.|:||....|:.|...||||.|:.|..|.|:|
Human   758 DCKECGKSFTSHSTLIQHQQIHTGEKLYDCKECGKSFTSHSTLIQHQPLHTGEKPYHCKECGKSF 822

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            |.:..|:.|...||||..:.|..|.|:||.:..::.|.|.||||.|:.|..|.|:|..:..:..|
Human   823 TLRSALIQHRPVHTGEKRYSCKECGKSFTSRSTLIEHQRIHTGEKPYHCKECGKSFAFRSAIIQH 887

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            .|.|||:.|:.|..|.|.|.|:..||.|.|:|||:.|::|..|.|.|.|...|..|...|:.:.|
Human   888 RRIHTGEKPYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSGLTKHHSIHTGEKP 952

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            :.|..|.|.|.::.||..| .|.||||||:.|:.|||||.....|:.|||:||.    |:|:.|:
Human   953 YECKTCGKSFRQRTHLTLH-QRIHTGDRPYECKECGKSFTCGSELIRHQRTHTG----EKPYDCK 1012

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            :|.|.|.|...|..|.|.|:|||.:.|..|.|||.....|.||..::
Human  1013 ECGKAFRCPSQLSQHKRIHTGEKTYQCPECGKAFFYASGLSRHQSVH 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	10/19 (53%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	171/422 (41%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381	35/95 (37%)
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368
		zf-H2C2_2	436..460	CDD:290200
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..487	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		zf-H2C2_2	493..516	CDD:290200
		C2H2 Zn finger	507..527	CDD:275368
		zf-H2C2_2	519..543	CDD:290200
		COG5048	531..947	CDD:227381	150/383 (39%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368	10/19 (53%)
		zf-H2C2_2	575..599	CDD:290200	10/23 (43%)
		C2H2 Zn finger	591..611	CDD:275368	7/19 (37%)
		C2H2 Zn finger	619..639	CDD:275368	5/19 (26%)
		zf-H2C2_2	632..656	CDD:290200	9/23 (39%)
		C2H2 Zn finger	647..667	CDD:275368	7/19 (37%)
		zf-H2C2_2	660..684	CDD:290200	12/23 (52%)
		C2H2 Zn finger	675..695	CDD:275368	6/19 (32%)
		zf-H2C2_2	687..711	CDD:290200	11/23 (48%)
		C2H2 Zn finger	703..723	CDD:275368	7/19 (37%)
		C2H2 Zn finger	732..751	CDD:275368	6/18 (33%)
		C2H2 Zn finger	759..779	CDD:275368	7/19 (37%)
		C2H2 Zn finger	787..807	CDD:275368	7/19 (37%)
		C2H2 Zn finger	815..835	CDD:275368	7/19 (37%)
		C2H2 Zn finger	843..863	CDD:275368	7/19 (37%)
		zf-H2C2_2	856..879	CDD:290200	10/22 (45%)
		C2H2 Zn finger	871..891	CDD:275368	6/19 (32%)
		C2H2 Zn finger	899..919	CDD:275368	9/19 (47%)
		zf-H2C2_2	912..936	CDD:290200	12/23 (52%)
		C2H2 Zn finger	927..947	CDD:275368	7/19 (37%)
		C2H2 Zn finger	955..975	CDD:275368	8/20 (40%)
		zf-H2C2_2	967..992	CDD:290200	16/25 (64%)
		C2H2 Zn finger	983..1003	CDD:275368	10/19 (53%)
		zf-H2C2_2	995..1020	CDD:290200	12/28 (43%)
		C2H2 Zn finger	1011..1031	CDD:275368	8/19 (42%)
		zf-H2C2_2	1024..1046	CDD:290200	10/21 (48%)
		C2H2 Zn finger	1039..1059	CDD:275368	8/19 (42%)
		zf-H2C2_2	1052..1076	CDD:290200	3/8 (38%)
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11996
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1498
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.890