DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZKSCAN2

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001012999.3	Gene:	ZKSCAN2 / 342357	HGNCID:	25677	Length:	967	Species:	Homo sapiens

Alignment Length:	248	Identity:	94/248 - (37%)
Similarity:	124/248 - (50%)	Gaps:	18/248 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 VNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTN 413
            |.|.|...|:.|:|.....:||.|....:.. |.|..:.|::|.||||.:.|...|..|.|.||.
Human   736 VVHQRPFVGKRPYRLLKYGESFGRSTRLMCR-MTHHKENPYKCGVCGKCFGRSRSLIRHQRIHTG 799

  Fly   414 ETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYC 478
            |.||:|..|||||:...:|..|...||||.|:||..|.|.|::...|:.|.|.||||.|::|..|
Human   800 EKPFKCLDCGKSFNDSSNFGAHQRIHTGEKPYRCGECGKCFSQSSSLIIHQRTHTGEKPYQCGEC 864

  Fly   479 MKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEH 543
            .|:||...|...|.|.||||.|:||..|.|:|........|.|.||||.|:.|..|.|.|::...
Human   865 GKSFTNSSHFSAHRRVHTGENPYKCVDCEKSFNNCTRFREHRRIHTGEKPYGCAQCGKRFSKSSV 929

  Fly   544 LTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPH--KCEYCQKTF 594
            ||.|...|..:.|               |.:...|:..::||  |.:..:|||
Human   930 LTKHREVHVREKP---------------LPHPPSLYCPENPHKGKTDEFRKTF 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	94/248 (38%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368	3/5 (60%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	1/19 (5%)
		C2H2 Zn finger	587..607	CDD:275368	3/8 (38%)
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZKSCAN2	NP_001012999.3	SCAN	41..148	CDD:128708
		SCAN	41..129	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..205
		KRAB_A-box	227..268	CDD:143639
		KRAB	<248..289	CDD:214630
		Myb_DNA-bind_4	340..421	CDD:290549
		Myb_DNA-bind_4	497..578	CDD:290549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..626
		COG5048	771..>957	CDD:227381	78/200 (39%)
		zf-C2H2	775..797	CDD:278523	9/21 (43%)
		C2H2 Zn finger	777..797	CDD:275368	9/19 (47%)
		zf-H2C2_2	789..813	CDD:290200	13/23 (57%)
		zf-C2H2	803..825	CDD:278523	9/21 (43%)
		C2H2 Zn finger	805..825	CDD:275368	8/19 (42%)
		zf-C2H2	831..853	CDD:278523	8/21 (38%)
		C2H2 Zn finger	833..853	CDD:275368	7/19 (37%)
		zf-H2C2_2	845..870	CDD:290200	12/24 (50%)
		C2H2 Zn finger	861..881	CDD:275368	8/19 (42%)
		zf-H2C2_2	873..898	CDD:290200	13/24 (54%)
		C2H2 Zn finger	889..909	CDD:275368	6/19 (32%)
		zf-H2C2_2	902..925	CDD:290200	10/22 (45%)
		C2H2 Zn finger	917..937	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..967		7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010