DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp780b

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001074490.1	Gene:	Zfp780b / 338354	MGIID:	2444764	Length:	806	Species:	Mus musculus

Alignment Length:	609	Identity:	203/609 - (33%)
Similarity:	284/609 - (46%)	Gaps:	57/609 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 QQVTVTTTSSSTSSGGSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAPDGTP- 215
            |.:|.....||||.|.:.::                  .||:.   :..:..||.:. ..:|.|
Mouse   115 QLITFDPKDSSTSIGPNYST------------------FHGLQ---DCQSDAGQQIT-NKEGVPP 157

  Fly   216 -----IATGT---HVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHI 272
                 :|..|   :.|..|||.|..|..|..|:..|:..||:.|:.||:.|...|.||||.|.|.
Mouse   158 HTCQTLAHNTEKPYECKECGKCFGCRSTLTQHQSIHTGEKPYECEECGKAFRLPQQLTRHQKSHS 222

  Fly   273 GGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQY 337
            |...|.|..|...|.....|:.|...|:.:|||.|..|.|:|.|..:|..|...|....|::|..
Mouse   223 GEKPFECNECGKAFHLPDLLKYHKTIHTGEKPFECRECGKSFNRVSNLVAHRIIHADVKPYKCSE 287

  Fly   338 CAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKE 402
            |.|.|.|:.::|.|.:.|:.|.|.:|..|.|.|........|...|||:...:|..|||.:...:
Mouse   288 CGKAFKRRSNLVQHQKTHSDERPFQCKDCGKGFIVLAQLTRHQNIHTGEKSFECHECGKAFRLPQ 352

  Fly   403 HLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQH 467
            .|..|.:||:.|.||:|..|||:|...:....|...||...|..|..|.|:|.|..:|:.|...|
Mouse   353 QLTRHQKSHSGEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLVEHRLIH 417

  Fly   468 TGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCT 532
            ....||:|:.|.|.|.|.:.|:.|.:.|:||.||:|..|.|||....|:..|...||||...:|.
Mouse   418 ADVKPHKCNECGKAFKRSKSLMQHQKIHSGERPFQCQECGKAFIVLTHLTRHQTIHTGEKSFECN 482

  Fly   533 YCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRK 597
            .|.|.|....||..|...|||:.|..|:.|.|.|..:.:|:.|.::|..:.|.||:.|...|.||
Mouse   483 ECGKKFRTATHLVMHQTIHTGEKPFECNVCGKAFRLQVYLSEHQKIHIEEKPFKCKLCGSAFRRK 547

  Fly   598 EHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQR 662
            ..||.|...|:.:.|:.|..|.|.|.::.:...|.| .|||::||.|:.|||.|.|...|:.||:
Mouse   548 YQLNEHYTIHTDEKPYQCKECGKCFRQRSNFTEHQS-IHTGNKPFECKECGKFFRLNTLLIRHQK 611

  Fly   663 SHTKGQEME------------------------RPFACEKCPKNFICKGHLVSHMRSHSGEKPHA 703
            ||:..:..:                        |||.|:.|.|:|..:..|:.|...|.|.|.:.
Mouse   612 SHSSERPYKCKECGKAFHLPSELNNHQIVHTSNRPFECKVCGKSFKRESTLIQHSVIHGGVKSYE 676

  Fly   704 CTLCSKAFVERGNLKRHMKMNHPD 727
            |..|.|||:.|.:|..|.|: |.|
Mouse   677 CNECGKAFIHRSSLFHHRKI-HSD 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	10/19 (53%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	155/446 (35%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
Zfp780b	NP_001074490.1	KRAB	14..75	CDD:214630
		C2H2 Zn finger	173..193	CDD:275368	8/19 (42%)
		COG5048	197..605	CDD:227381	151/408 (37%)
		C2H2 Zn finger	201..221	CDD:275368	10/19 (53%)
		C2H2 Zn finger	229..249	CDD:275368	5/19 (26%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		C2H2 Zn finger	313..333	CDD:275368	5/19 (26%)
		C2H2 Zn finger	341..361	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..585	CDD:275368	6/20 (30%)
		C2H2 Zn finger	593..613	CDD:275368	9/19 (47%)
		C2H2 Zn finger	621..641	CDD:275368	0/19 (0%)
		C2H2 Zn finger	649..669	CDD:275368	6/19 (32%)
		C2H2 Zn finger	677..697	CDD:275368	9/20 (45%)
		C2H2 Zn finger	705..725	CDD:275368
		C2H2 Zn finger	733..753	CDD:275368
		C2H2 Zn finger	761..781	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950