DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Gm14325

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001020020.2	Gene:	Gm14325 / 329575	MGIID:	3702875	Length:	498	Species:	Mus musculus

Alignment Length:	445	Identity:	174/445 - (39%)
Similarity:	239/445 - (53%)	Gaps:	5/445 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 TSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHF 324
            ||:...||.:..........|.|...||..:..:||..:|:.:|...|..|.|.|.....|..|.
Mouse    58 TSRSHGRHERSCSAEQPSEFIQCGKAFAYESGRQRHQIKHTGEKHHDCNQCGKDFRTWNVLQIHK 122

  Fly   325 RSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPH 389
            |:||||.|:.|:.|.|.|.|..|:..|.|.|.||..:.|:.|.|:|.|:.....|...|||:.|:
Mouse   123 RTHTGEKPYDCKQCGKAFARSCHLRIHNRTHAGEKQYECNQCGKAFKRRSDLQIHKRTHTGEKPY 187

  Fly   390 QCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTF 454
            :|..|||.:.....|..|.|:||.|.|:.|:.|||:||:..|...|...||||.|:.|:.|.|.|
Mouse   188 ECKQCGKAFVSSGELQKHKRTHTGEKPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQCGKAF 252

  Fly   455 TRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNH 519
            .|...|..|.|.||||.|:.|..|.|.|....||..|.|:|||:.|::|..|.|||.....:..|
Mouse   253 ARSGDLQKHKRTHTGEKPYECKQCGKAFAHSSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMH 317

  Fly   520 VRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSP 584
            .|.|||:.|::|..|.|.||....|..|.:.|||:.|:.|..|.|||::..||..|.|.|||:.|
Mouse   318 KRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCGKTFSQSRHLRIHKRTHTGEKP 382

  Fly   585 HKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGK 649
            ::|..|.|.|.|......|.|.|:.:.|:.||.|.|.|.|:..|..| .|.|||::|:.|:.|||
Mouse   383 YECNQCGKAFARSGDQQEHKRTHTGEKPYECNQCGKAFIRRRVLQIH-KRTHTGEKPYECKQCGK 446

  Fly   650 SFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHAC 704
            :|....:|..|:|:|:.    |:|:.|::|.|.|....||..|.::|:||:|:.|
Mouse   447 AFASSSDLQKHKRTHSG----EKPYECKQCGKAFAQSSHLRIHKQTHTGERPYEC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	4/10 (40%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	163/405 (40%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	1/1 (100%)
Gm14325	NP_001020020.2	KRAB	5..>45	CDD:214630
		KRAB	5..43	CDD:279668
		COG5048	74..459	CDD:227381	154/385 (40%)
		C2H2 Zn finger	79..97	CDD:275368	5/17 (29%)
		C2H2 Zn finger	105..125	CDD:275368	7/19 (37%)
		zf-H2C2_2	118..142	CDD:290200	12/23 (52%)
		C2H2 Zn finger	133..153	CDD:275368	8/19 (42%)
		C2H2 Zn finger	161..181	CDD:275368	6/19 (32%)
		zf-H2C2_2	173..198	CDD:290200	9/24 (38%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		zf-H2C2_2	201..226	CDD:290200	12/24 (50%)
		C2H2 Zn finger	217..237	CDD:275368	8/19 (42%)
		zf-H2C2_2	229..254	CDD:290200	11/24 (46%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		zf-H2C2_2	257..282	CDD:290200	12/24 (50%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	314..337	CDD:290200	9/22 (41%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	11/23 (48%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..422	CDD:290200	9/22 (41%)
		C2H2 Zn finger	413..433	CDD:275368	9/20 (45%)
		zf-H2C2_2	426..450	CDD:290200	12/24 (50%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-H2C2_2	453..478	CDD:290200	10/28 (36%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900