DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp182

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_036017871.1	Gene:	Zfp182 / 319535	MGIID:	2442220	Length:	682	Species:	Mus musculus

Alignment Length:	556	Identity:	207/556 - (37%)
Similarity:	291/556 - (52%)	Gaps:	56/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 QVTVTTTSSSTSSGGSTTS--GGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAPDGTP 215
            ||.:...:..|.||.:.|.  .....:.| ||:|....  |..:..||          ...|...
Mouse   177 QVRLPNDNIITKSGQNYTDFRNAFHLSTG-LLVPMQRS--HKFESFGN----------TMVDNLN 228

  Fly   216 IATGTHVCDI----CGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPM 276
            :.||:...:.    |.|.|       .|..|  |...|:.:.|  |:...:...|..|
Mouse   229 LLTGSSTENKHDTGCAKFF-------FHTEY--ENPNFIVKPC--GYKEYEKTLRQKK------- 275

  Fly   277 FTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKT 341
                          .|..|.:..:.::||.||.|||||::|.||..|:|:||||.||.|..|.|.
Mouse   276 --------------GLSLHQRIKNGERPFECTACQKTFSKKSHLIVHWRTHTGEKPFECSECGKA 326

  Fly   342 FTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLAN 406
            |::|..::.|:|.||||.|..|..|.|:|..|...:.||..|||:.|::|:.|||.:|:|.:|..
Mouse   327 FSQKSQLIIHLRTHTGERPFACPECGKAFREKSTVIIHYRTHTGEKPYECNQCGKAFTQKSNLIV 391

  Fly   407 HMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGES 471
            |.::||.|..:.|..||:||.:|.....|...|||:.||.|..|.|||:.|..|:.|.|.||||.
Mouse   392 HQKTHTGEKTYECTKCGESFIQKLDLIIHHSTHTGKKPHECSECKKTFSDKSTLVIHQRTHTGEK 456

  Fly   472 PHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTK 536
            ||:|:.|.|:|..|..|:.|.|.||||.|::|..|.|.||:|.::..|.|.|:||.|.:|..|.|
Mouse   457 PHKCTECGKSFNEKSTLIVHQRIHTGEKPYECDVCGKTFTQKSNLGVHQRTHSGEKPFECNECEK 521

  Fly   537 TFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLN 601
            .|::|.:|..|.|.|||:.|:.|:.|:|.|::|.:|..|.|.||.:.|:||..|.|.|..|..|.
Mouse   522 AFSQKSYLMLHQRGHTGEKPYECNECEKAFSQKSYLIIHQRTHTEEKPYKCNECGKAFREKSKLI 586

  Fly   602 NHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTK 666
            .|.|.|:.:.|:.|.||.|.|::|..||.| .|.|||::|:.|..|||:|..|.....|||:||.
Mouse   587 IHQRIHTGEKPYECLVCWKAFSQKSQLIIH-QRTHTGEKPYECTECGKAFREKSTFTVHQRTHTG 650

  Fly   667 GQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPH 702
                |:|:.|.:|.|.|..|.:|:.|.|:|:.:|.|
Mouse   651 ----EKPYKCIECGKAFTQKSNLIVHQRTHTVKKAH 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/23 (17%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	2/19 (11%)
		COG5048	300..723	CDD:227381	178/403 (44%)
		C2H2 Zn finger	307..327	CDD:275368	12/19 (63%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368
Zfp182	XP_036017871.1	KRAB	63..139	CDD:214630
		COG5048	288..677	CDD:227381	175/393 (45%)
		C2H2 Zn finger	292..312	CDD:275368	12/19 (63%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	8/19 (42%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		C2H2 Zn finger	460..480	CDD:275368	8/19 (42%)
		C2H2 Zn finger	488..508	CDD:275368	8/19 (42%)
		C2H2 Zn finger	516..536	CDD:275368	8/19 (42%)
		C2H2 Zn finger	544..564	CDD:275368	8/19 (42%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		C2H2 Zn finger	600..620	CDD:275368	10/20 (50%)
		C2H2 Zn finger	628..648	CDD:275368	9/19 (47%)
		C2H2 Zn finger	656..676	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860