DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF763

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001012771.1	Gene:	ZNF763 / 284390	HGNCID:	27614	Length:	397	Species:	Homo sapiens

Alignment Length:	400	Identity:	115/400 - (28%)
Similarity:	171/400 - (42%)	Gaps:	44/400 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 PFMCQVCGQGFTTSQ----DLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACT 308
            |..|:.....||..:    |:::. |::..       |....|.|.||:.:..|..:.:..:
Human     6 PVACEDVAVNFTQEEWALLDISQR-KLYRE-------VMLETFRNLTSIGKKWKDQNIEYEY--- 59

  Fly   309 ICQKTFARKEHLDNHFRS----HTGETPFRCQYCAKTFTR-KEHMVNHVRKHTGETPHRCD--IC 366
                     ::...:|||    :..|.. ...:|.:|||: .:..:|...|........||  :|
Human    60 ---------QNPRRNFRSLIEGNVNEIK-EDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVC 114

  Fly   367 ------KKSFTRK-----EHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCE 420
                  ..||...     .|....|..:..: |::|....|.:..........|:||.|.|:.|:
Human   115 GEVGIGNSSFNMNIRGDIGHKAYEYQDYAPK-PYKCQQPKKAFRYHPSFRTQERNHTGEKPYACK 178

  Fly   421 ICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRK 485
            .|||:|.........::.|:|:.|::|.||.|........|.|.|.||||.|:.|..|:|:|:..
Human   179 ECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPYECKQCVKSFSYS 243

  Fly   486 EHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQ 550
            .....|.|.||||.|::|..|.|||........|.|.|||..|::|..|.|:|:.......|.|.
Human   244 ATHRIHERTHTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERT 308

  Fly   551 HTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCC 615
            |||:.|..||.|.|.|........|.|.|||:.|::|:.|:|.||....|..|.|.||:..|:.|
Human   309 HTGEKPCECSKCNKAFRSYRSYLRHKRSHTGEKPYQCKECRKAFTYPSSLRRHERTHSAKKPYEC 373

  Fly   616 NVCNKPFTRK 625
            ..|.|..:.|
Human   374 KQCGKALSYK 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	5/23 (22%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	102/343 (30%)
		C2H2 Zn finger	307..327	CDD:275368	3/23 (13%)
		C2H2 Zn finger	335..355	CDD:275368	5/20 (25%)
		C2H2 Zn finger	363..383	CDD:275368	7/32 (22%)
		C2H2 Zn finger	391..411	CDD:275368	3/19 (16%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	3/10 (30%)
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF763	NP_001012771.1	KRAB	7..>49	CDD:214630	10/49 (20%)
		KRAB	7..46	CDD:279668	9/46 (20%)
		C2H2 Zn finger	149..169	CDD:275368	3/19 (16%)
		COG5048	202..>390	CDD:227381	70/181 (39%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..242	CDD:290200	11/20 (55%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		zf-H2C2_2	247..270	CDD:290200	12/22 (55%)
		C2H2 Zn finger	261..281	CDD:275368	7/19 (37%)
		zf-H2C2_2	273..297	CDD:290200	9/23 (39%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		zf-H2C2_2	301..326	CDD:290200	11/24 (46%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		zf-H2C2_2	332..354	CDD:290200	10/21 (48%)
		DUF45	<342..383	CDD:302795	15/40 (38%)
		C2H2 Zn finger	345..365	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900