DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF841

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001356754.1	Gene:	ZNF841 / 284371	HGNCID:	27611	Length:	925	Species:	Homo sapiens

Alignment Length:	558	Identity:	208/558 - (37%)
Similarity:	289/558 - (51%)	Gaps:	61/558 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            ||:||::|:....|:.|||.|:..||::|..||:.|:.|..|..|.:||.|...:.|..|...|:
Human   320 CDVCGRIFRQNSDLVNHRRSHTGDKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNRCGKCFS 384

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            .::||..|...|:.|||:.|..|.|||.|...|..|...|.|:.|:.|..|.|.|.:...:|.|.
Human   385 QSSSLATHQTVHTGDKPYKCNECGKTFKRNSSLTAHHIIHAGKKPYTCDVCGKVFYQNSQLVRHQ 449

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            ..||||||::|:.|.|.|.::.....|...|||:.|::|:.|||.:::..|||.|.|.||.|.|:
Human   450 IIHTGETPYKCNECGKVFFQRSRLAGHRRIHTGEKPYKCNECGKVFSQHSHLAVHQRVHTGEKPY 514

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSK----------------------------TF 454
            :|..|||:|:.....|.|...||||.|::|:.|.|                            .|
Human   515 KCNECGKAFNWGSLLTVHQRIHTGEKPYKCNVCGKVFNYGGYLSVHMRCHTGEKPLHCNKCGMVF 579

  Fly   455 TRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNH 519
            |....|..|.|.||||.|::|:.|.|.|....:|..|.|.||||.||:|..|.|.|:....:..|
Human   580 TYYSCLARHQRMHTGEKPYKCNVCGKVFIDSGNLSIHRRSHTGEKPFQCNECGKVFSYYSCLARH 644

  Fly   520 VRQHTGESPHKCTYCTKTFTRKEHLTNHV----------------------------RQHTGDSP 556
            .:.||||.|:||..|.|.:|::..||.|:                            |..||:.|
Human   645 RKIHTGEKPYKCNDCGKAYTQRSSLTKHLVIHTGENPYHCNEFGEAFIQSSKLARYHRNPTGEKP 709

  Fly   557 HRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKP 621
            |:||.|.:||:.|..|..|.|.|||:.|:||..|.|.|.....|..|.|.|:.:.|:.||.|.|.
Human   710 HKCSECGRTFSHKTSLVYHQRRHTGEMPYKCIECGKVFNSTTTLARHRRIHTGEKPYKCNECGKV 774

  Fly   622 FTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICK 686
            |..:..|..|.| .|||::|:.|..|||:|.::..||.||..||.    |:|:.|.:|.|.||.:
Human   775 FRYRSGLARHWS-IHTGEKPYKCNECGKAFRVRSILLNHQMMHTG----EKPYKCNECGKAFIER 834

  Fly   687 GHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            .:||.|.|:|:||||:.|..|.|||..|..|.:|.:::
Human   835 SNLVYHQRNHTGEKPYKCMECGKAFGRRSCLTKHQRIH 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	179/478 (37%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/47 (17%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	8/47 (17%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	9/19 (47%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF841	NP_001356754.1	KRAB	8..69	CDD:214630
		COG5048	260..636	CDD:227381	118/315 (37%)
		C2H2 Zn finger	265..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368	9/19 (47%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..452	CDD:275368	6/19 (32%)
		C2H2 Zn finger	460..480	CDD:275368	5/19 (26%)
		COG5048	484..886	CDD:227381	145/394 (37%)
		C2H2 Zn finger	488..508	CDD:275368	9/19 (47%)
		C2H2 Zn finger	516..536	CDD:275368	7/19 (37%)
		C2H2 Zn finger	544..564	CDD:275368	3/19 (16%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		C2H2 Zn finger	628..648	CDD:275368	5/19 (26%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		C2H2 Zn finger	712..732	CDD:275368	9/19 (47%)
		C2H2 Zn finger	740..760	CDD:275368	7/19 (37%)
		C2H2 Zn finger	768..788	CDD:275368	8/20 (40%)
		C2H2 Zn finger	796..816	CDD:275368	9/19 (47%)
		C2H2 Zn finger	824..844	CDD:275368	9/19 (47%)
		C2H2 Zn finger	852..872	CDD:275368	8/19 (42%)
		C2H2 Zn finger	880..900	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860