DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF337

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001277190.1	Gene:	ZNF337 / 26152	HGNCID:	15809	Length:	751	Species:	Homo sapiens

Alignment Length:	502	Identity:	188/502 - (37%)
Similarity:	273/502 - (54%)	Gaps:	5/502 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 GTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCF 283
            |...|...|:.|..:..:|:|::.||.:|.|.|:.|.|||.....|..|...|.|...:.|.||.
Human   178 GAFKCAERGQDFSRKMMVIIHKKAHSRQKLFTCRECHQGFRDESALLLHQNTHTGEKSYVCSVCG 242

  Fly   284 NVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHM 348
            ..|:...:|.||.:.||.:|||.|.:|.:.:..|.:|..|.|:||||.|:.||.|.:.|..|...
Human   243 RGFSLKANLLRHQRTHSGEKPFLCKVCGRGYTSKSYLTVHERTHTGEKPYECQECGRRFNDKSSY 307

  Fly   349 VNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTN 413
            ..|::.|:||.|..|..|.:.:|.|.::|.|...|:|:.|::|..||:.::.|.||..|.|:|:.
Human   308 NKHLKAHSGEKPFVCKECGRGYTNKSYFVVHKRIHSGEKPYRCQECGRGFSNKSHLITHQRTHSG 372

  Fly   414 ETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYC 478
            |.||.|..|.:|||.|.....|...|:||.|..|..|.::|::|..|:.|.|.|:||.|..|..|
Human   373 EKPFACRQCKQSFSVKGSLLRHQRTHSGEKPFVCKDCERSFSQKSTLVYHQRTHSGEKPFVCREC 437

  Fly   479 MKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEH 543
            .:.|.:|..||.|...|:.|.||.|..|.:.|.:|.....|.|.|:.|.|:.|..|.:.|..|..
Human   438 GQGFIQKSTLVKHQITHSEEKPFVCKDCGRGFIQKSTFTLHQRTHSEEKPYGCRECGRRFRDKSS 502

  Fly   544 LTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHS 608
            ...|:|.|.|:....|..|.:.||.|.:||.|.|.|:|:.|..|:.|:|:|:.|.:|..|...||
Human   503 YNKHLRAHLGEKRFFCRDCGRGFTLKPNLTIHQRTHSGEKPFMCKQCEKSFSLKANLLRHQWTHS 567

  Fly   609 SDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERP 673
            .:.|..|..|.:.|..|..|:.| .:.|:|::||.|..||:.|..|.||:.||.:|:..|    |
Human   568 GERPFNCKDCGRGFILKSTLLFH-QKTHSGEKPFICSECGQGFIWKSNLVKHQLAHSGKQ----P 627

  Fly   674 FACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRH 720
            |.|::|.:.|..||:|::|.|:||||||..|.:|.:.|..:.:|.||
Human   628 FVCKECGRGFNWKGNLLTHQRTHSGEKPFVCNVCGQGFSWKRSLTRH 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		COG5048	300..723	CDD:227381	161/421 (38%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
ZNF337	NP_001277190.1	zf-H2C2_2	699..724	CDD:290200
		C2H2 Zn finger	715..735	CDD:275368
		KRAB	12..71	CDD:214630
		KRAB	12..51	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..163
		C2H2 Zn finger	182..202	CDD:275368	5/19 (26%)
		C2H2 Zn finger	210..230	CDD:275368	7/19 (37%)
		COG5048	234..626	CDD:227381	146/392 (37%)
		C2H2 Zn finger	238..258	CDD:275368	7/19 (37%)
		zf-H2C2_2	250..275	CDD:290200	10/24 (42%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	278..302	CDD:290200	11/23 (48%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		zf-C2H2	348..370	CDD:278523	8/21 (38%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	8/24 (33%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	462..482	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..510	CDD:275368	6/19 (32%)
		C2H2 Zn finger	518..538	CDD:275368	9/19 (47%)
		zf-H2C2_2	530..554	CDD:290200	10/23 (43%)
		C2H2 Zn finger	546..566	CDD:275368	7/19 (37%)
		C2H2 Zn finger	574..594	CDD:275368	6/20 (30%)
		DUF4193	<600..633	CDD:290546	15/36 (42%)
		C2H2 Zn finger	602..622	CDD:275368	9/19 (47%)
		C2H2 Zn finger	630..650	CDD:275368	8/19 (42%)
		zf-H2C2_2	642..666	CDD:290200	11/23 (48%)
		C2H2 Zn finger	658..679	CDD:275368	6/17 (35%)
		C2H2 Zn finger	687..707	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860