DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF500

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_067678.1	Gene:	ZNF500 / 26048	HGNCID:	23716	Length:	480	Species:	Homo sapiens

Alignment Length:	143	Identity:	58/143 - (40%)
Similarity:	79/143 - (55%)	Gaps:	0/143 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 HTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRC 447
            |....|:.|..|||.:::..||..|.|:||.|.|::|.:|||.||.:.:|:.|...||||.|:.|
Human   319 HGADKPYTCPECGKGFSKTSHLTKHQRTHTGERPYKCLVCGKGFSDRSNFSTHQRVHTGEKPYPC 383

  Fly   448 DFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTR 512
            ..|.|.|::...|:.|.|.|:||.|:.|:.|.|.|....|...|.|.||||.|:.|..|.:.|.|
Human   384 PECGKRFSQSSSLVIHRRTHSGERPYACTQCGKRFNNSSHFSAHRRTHTGEKPYTCPACGRGFRR 448

  Fly   513 KDHMVNHVRQHTG 525
            ...:..|.|.|.|
Human   449 GTDLHKHQRTHMG 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	58/143 (41%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368
		C2H2 Zn finger	363..383	CDD:275368	58/143 (41%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368
		C2H2 Zn finger	559..579	CDD:275368
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF500	NP_067678.1	SCAN	46..151	CDD:128708
		SCAN	46..134	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..208
		KRAB_A-box	224..>247	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..268
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..322		1/2 (50%)
		COG5048	<320..459	CDD:227381	55/138 (40%)
		zf-C2H2	325..347	CDD:278523	8/21 (38%)
		C2H2 Zn finger	327..347	CDD:275368	8/19 (42%)
		zf-H2C2_2	339..363	CDD:290200	12/23 (52%)
		C2H2 Zn finger	355..375	CDD:275368	8/19 (42%)
		zf-H2C2_2	367..392	CDD:290200	11/24 (46%)
		C2H2 Zn finger	383..403	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..420	CDD:290200	11/24 (46%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		zf-H2C2_2	423..448	CDD:290200	11/24 (46%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..480		4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100