DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp53

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_038871.1	Gene:	Zfp53 / 24132	MGIID:	99200	Length:	652	Species:	Mus musculus

Alignment Length:	496	Identity:	181/496 - (36%)
Similarity:	267/496 - (53%)	Gaps:	18/496 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 TGTHVC--DICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQG-----FTTSQDLTRHGKIHIGGP 275
            ||..:|  :.|.|.......|..::|.::..|     :..||     |::...|.:. .|:||..
Mouse   166 TGEELCKSEDCEKSLSLSSNLTENQRLYAANK-----LQSQGEYDDDFSSVYSLMQQ-TIYIGDT 224

  Fly   276 MFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAK 340
            ...|..|...|:..:||..|.:.|:..||:.|::|.|:|.:..:|..|.|.||||.|::|:.|.|
Mouse   225 PHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSVCGKSFTQCTNLKTHQRLHTGEKPYKCKECGK 289

  Fly   341 TFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLA 405
            :|.:...:.:|.:.||||.|::|..|.|||.....:..|...|..:....|..|||...:..||.
Mouse   290 SFPQLSALKSHQKIHTGERPYKCKECDKSFAHCSSFRRHQKTHRAEEHCSCPECGKVLHQLSHLR 354

  Fly   406 NHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGE 470
            :|.|.||.|.|::|..|.:||:....:..|...|:.:..::|..|.|:|....||..|.|.||||
Mouse   355 SHYRLHTGEKPYKCNECDRSFTYYASYRRHQKTHSLDKFYKCKECGKSFLELSHLKRHYRIHTGE 419

  Fly   471 SPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCT 535
            .|::|..|.|:||....|..|::.||||.||||..|.|:||:..|:..|...||||.|::|..|.
Mouse   420 KPYKCEVCDKSFTVNSTLKTHLKIHTGEKPFKCRECDKSFTKCSHLRRHQSVHTGEKPYRCKECD 484

  Fly   536 KTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHL 600
            |:||....|..|.:.|||:.|::|..|.|:|.::.:|..|.|:|||:.|:.|:.|.|:||:...|
Mouse   485 KSFTECSTLRAHQKIHTGEKPYKCRECDKSFIQRSNLIIHQRVHTGERPYICKECGKSFTKCSTL 549

  Fly   601 NNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHT 665
            ..|.:.|:.:.|:.|..|||.||:..||..| .|.|||:||:.|:.|||||.....|..||:.||
Mouse   550 QIHQKIHTGEKPYKCMECNKSFTQDSHLRTH-QRVHTGERPYICKECGKSFTRCSYLRAHQKIHT 613

  Fly   666 KGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTL 706
            .    |:|:.|:.|..:||...:|..|.|.|:|||....|:
Mouse   614 G----EKPYKCKDCDISFIQISNLRRHQRVHTGEKNTIATI 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/21 (24%)
		C2H2 Zn finger	251..271	CDD:275368	4/24 (17%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	159/407 (39%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	1/3 (33%)
Zfp53	NP_038871.1	KRAB	53..93	CDD:396083
		COG5048	223..627	CDD:227381	156/408 (38%)
		C2H2 Zn finger	228..248	CDD:275368	6/19 (32%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	5/19 (26%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	370..388	CDD:275368	4/17 (24%)
		C2H2 Zn finger	396..416	CDD:275368	8/19 (42%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	536..556	CDD:275368	7/19 (37%)
		C2H2 Zn finger	564..584	CDD:275368	10/20 (50%)
		C2H2 Zn finger	592..612	CDD:275368	9/19 (47%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950