DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp760

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_030105629.1	Gene:	Zfp760 / 240034	MGIID:	2679257	Length:	671	Species:	Mus musculus

Alignment Length:	499	Identity:	192/499 - (38%)
Similarity:	269/499 - (53%)	Gaps:	33/499 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 CGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNT 290
            |||.|:....|..|:|.|:..||:.|:.||:.|.....|..|.:||.|
Mouse   190 CGKCFRSCSSLSTHQRLHTGEKPWKCKECGKSFKWLSHLKAHCRIHTG----------------- 237

  Fly   291 SLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKH 355
                       :|||.|..|.|.|:|...|.:|:|:||||.|::|:.|.|.|:|...:.||.|.|
Mouse   238 -----------EKPFKCNECDKGFSRLSRLKSHYRTHTGEKPYKCEECGKCFSRLSRLKNHYRIH 291

  Fly   356 TGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCE 420
            |||.|::|..|.||||.......|...|||:.||:|..|||.:.....|..|.|.||.|.|::|:
Mouse   292 TGEKPYKCKECGKSFTHCTGLSTHQKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREKPYKCK 356

  Fly   421 ICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRK 485
            .|||.|.......:|...||||||::|..|.|:|::...|.:|.|.||||...:|..|.|.||:.
Mouse   357 ECGKFFHWLSGLKSHYRIHTGETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQC 421

  Fly   486 EHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQ 550
            ..|..|.:.||.|.|:||..|:|.|....|:.:|.|.||||.|:||..|.|..::...|.:|.|.
Mouse   422 TALKRHQKIHTDEKPYKCEECSKCFYVLSHLKSHCRTHTGEKPYKCEECGKCLSQLSKLKSHYRI 486

  Fly   551 HTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCC 615
            |||:.|::|..|.|:||....|:.|.::|||:.|:.|:.|.|:|.....|..|.|.|:.:.|:.|
Mouse   487 HTGEKPYKCKECDKSFTHCTALSTHQKIHTGEKPYSCKDCGKSFYLLSRLKEHYRVHTGEKPYNC 551

  Fly   616 NVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCP 680
            ..|.|.|....:|..| ||.|||::|:.||.|.|||....:|..||:.|..    .:|:.||:|.
Mouse   552 KECGKFFHWLSNLKRH-SRIHTGEKPYKCEECDKSFTHCSSLKAHQKIHAG----VKPYKCEECS 611

  Fly   681 KNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            |:|....:|.:|.|.|:||||:.|..|.|:|.:|..|.:|.:::
Mouse   612 KSFYWLSNLKTHSRIHTGEKPYKCGKCDKSFTQRSLLTKHNRIH 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/16 (44%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	173/422 (41%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Zfp760	XP_030105629.1	KRAB	12..52	CDD:396083
		C2H2 Zn finger	137..182	CDD:275368
		C2H2 Zn finger	188..207	CDD:275368	7/16 (44%)
		COG5048	211..586	CDD:227381	157/403 (39%)
		C2H2 Zn finger	215..235	CDD:275368	6/19 (32%)
		C2H2 Zn finger	243..263	CDD:275368	8/19 (42%)
		C2H2 Zn finger	271..291	CDD:275368	8/19 (42%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		C2H2 Zn finger	355..375	CDD:275368	6/19 (32%)
		C2H2 Zn finger	383..403	CDD:275368	7/19 (37%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		C2H2 Zn finger	439..459	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
		C2H2 Zn finger	551..571	CDD:275368	8/20 (40%)
		SFP1	<573..623	CDD:227516	19/53 (36%)
		C2H2 Zn finger	579..599	CDD:275368	9/19 (47%)
		C2H2 Zn finger	607..627	CDD:275368	8/19 (42%)
		zf-H2C2_2	619..644	CDD:404364	12/24 (50%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950